Update on Laser Photochemotherapy: An Alternative for Cancer Treatment

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Update on Laser Photochemotherapy: An Alternative for Cancer Treatment



Anti-Cancer Agents in Medicinal Chemistry, 11(8): 772-779.

Author(s): Marcos B. Paiva, Jayne Joo, Marcio Abrahao, Joao Carlos Ribeiro, Onivaldo Cervantes and Joel A Sercarz.

Affiliation: Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue 62-132, Los Angeles, CA 90095-1624, USA.

Abstract

Although major progress has been made in surgery, radiation, and chemotherapy for the treatment of malignancy during the last 20 years, there has been little improvement in the survival of patients with recurrent or advanced head and neck cancer. Because of the ease and accessibility for surgery and their loco-regional biological behavior, head and neck cancers serve as an ideal model to test combined laser energy delivered via interstitial fiberoptics and chemotherapeutic agents activated by photo-thermal energy as an alternative, less invasive treatment for cancer. A number of investigators have shown that anthracyclines and cisplatin are likely candidates for light or heat activation in cancer cells. Maximum tolerated dose followed by photochemical and thermal activation via laser fiberoptics can improve treatment by sensitizing tumor response. The higher intratumor drug levels compared to systemic drug administration along with laser activation should also reduce systemic toxicity. In this article the authors analyze the concept of combining anti-cancer drugs and laser therapy and review the clinical application. In summary, the literature available suggests photochemotherapy with currently approved drugs and lasers may soon become an attractive alternative for cancer treatment.

Keywords:

Photochemotherapy, combined intratumor therapy, cisplatin, laser-induced thermal therapy, lasers, fiberoptics, photosensitize tumors, chemotherapy, hypopharynx.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 11
Issue Number: 8
First Page: 772
Last Page: 779
Page Count: 8
DOI: 10.2174/187152011797378742
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science