Nanoparticles in Oncology: The New Theragnostic Molecules

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Nanoparticles in Oncology: The New Theragnostic Molecules



Anti-Cancer Agents in Medicinal Chemistry, 11(7): 669-686.

Author(s): Alessandro Allegra, Giuseppa Penna, Andrea Alonci, Vincenzo Rizzo, Sabina Russo and Caterina Musolino.

Affiliation: Via Colapesce 20, Messina, Italy.

Abstract

Cancer nanotherapeutics have shown promise in resolving some of the limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, low therapeutic indices, and poor oral bioavailability. Moreover, cancer nanotechnology has the potential of improving current approaches to cancer detection, diagnosis, and imaging. Recently, nanotechnology and molecular imaging have been combined to generate nanoparticles that simultaneously facilitate cancer therapy and diagnosis, the so called theragnostic nanoparticles. The aim of our review is to highlight recent developments within the context of the current knowledge of nanotechnology, to recall the experimental steps that have brought to the clinical development and application of nanoparticles, and explain the biological rationale for their use with oncologic patients. In particular, we summarize recent findings with respect to possible new applications for therapy and diagnosis, and their specific properties. Moreover, we report the more recent prospects in gene therapy, the possibility of using new drug delivery methods, the action of nanoparticles on the immune system and apoptosis, and the concrete possibility of detecting and characterizing circulating tumor cells or of developing new technologies in drug discovery.

Keywords:

Drug delivery, gene therapy, imaging, nanoparticles, nanovectors, nanotechnology, theragnostic molecules, chitosan-based nanoparticles (CNPs), polyethylene glycol PEG, Docetaxel, Magnetic drug targeting (MDT).



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Article Details

Volume: 11
Issue Number: 7
First Page: 669
Last Page: 686
Page Count: 18
DOI: 10.2174/187152011796817682
Price: $58
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