Clinical Importance and Potential Use of Small Molecule Inhibitors of Focal Adhesion Kinase

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Clinical Importance and Potential Use of Small Molecule Inhibitors of Focal Adhesion Kinase

Anti-Cancer Agents in Medicinal Chemistry, 11(7): 593-599.

Author(s): Alexander Schultze and Walter Fiedler.

Affiliation: University Medical Center Hamburg - Eppendorf, Hubertus Wald University Cancer Center Hamburg, Department of Oncology/Hematology with Sections BMT and Pneumology, 20246 Hamburg, Germany.


Since its first description Focal Adhesion Kinase (FAK), a cytoplasmatic tyrosine kinase, has been implicated in the formation and progression of solid and liquid malignant tumors. Therefore orally available selective small molecule inhibitors of FAK have been developed, three of them (PF-562-271, PF-04554878 and GSK2256098) are already in clinical testing. This review discusses the recent data obtained from these Phase 1 trials. We also discuss available data on the mechanisms of action of these inhibitors in carcinogenesis and demonstrate that FAK plays an important role in neoangiogenesis which is a crucial step in cancer growth.


Angiogenesis, Chemoresistance, Focal Adhesion Kinase, Metastasis, Migration of tumor cells, Small molecule inhibitors, FAK, neoangiogenesis, PF-04554878, PF-562,271.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 7
First Page: 593
Last Page: 599
Page Count: 7
DOI: 10.2174/187152011796817727
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science