Role of Stem Cells in Normal Liver and Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Role of Stem Cells in Normal Liver and Cancer

Anti-Cancer Agents in Medicinal Chemistry, 11(6): 522-528.

Author(s): Chi Keung Lau, Zhen Fan Yang and Sheung Tat Fan.

Affiliation: Department of Surgery, The University of Hong Kong, 21 Sassoon Road, Hong Kong.


Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and non-surgical ones, cannot effectively cure this disease. Increasing evidence has revealed the importance of cancer stem cells (CSCs) in hepatocarcinogenesis, and the idea of targeting CSCs sheds light on more effective therapeutic strategies for HCC. In this review, normal stem cells and putative CSCs in the liver are briefly introduced. Studies about signaling pathways that regulate pathophysiological activities of liver CSCs and the therapeutic potential by targeting CSCs are also summarized and discussed.


Normal stem cells, cancer stem cells, hepatocellular carcinoma, Epidemiology, chemoembolization, angiogenesis, hydrolase, EpCAM, CD13, CD90, NOTCH, OVAL CELLS, PTEN, TGF.

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Article Details

Volume: 11
Issue Number: 6
First Page: 522
Last Page: 528
Page Count: 7
DOI: 10.2174/187152011796011091
Price: $58

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