Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis



Anti-Cancer Agents in Medicinal Chemistry, 11(3): 272-279.

Author(s): Govardhan K. Shroff, Ramyasri Kuna, Kethora Dirsipam, Ravishekar Yalagala and Prasenjit Mitra.

Affiliation: Chemical Biology Division, Institute of Life Sciences, Hyderabad, University of Hyderabad campus, Gachibowli, Hyderabad, 500032, India.

Abstract

Altered cellular metabolism is a hallmark of tumorigenesis. Described first in 1924 by Otto Warburg, a cancer cell undergoes complete metabolic reprogramming to attain nutrient self-sufficiency for proliferation and survival. Interplay between diverse signalling cascades confers this metabolic advantage. In this review we focus on signalling molecules that regulate this altered metabolic paradigm in a cancer cell with emphasis on small molecule mediated intervention for attenuation of growth and progression of tumor.

Keywords:

Warburg effect, glutaminolysis, aerobic glycolysis, Myc, Akt, mTOR, Hexokinase II, SGLT2 expression, mitochondrial outer membrane, isozymes, Fibroblast growth factor receptor (FGFR), Pyruvate kinase, tumor cell populations, hypoxic tumor cells.



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Article Details

Volume: 11
Issue Number: 3
First Page: 272
Last Page: 279
Page Count: 8
DOI: 10.2174/187152011795347531
Price: $58
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