Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins



Anti-Cancer Agents in Medicinal Chemistry, 11(2): 222-232.

Author(s): Jonathan F. Arambula, Christian Preihs, Derric Borthwick, Darren Magda and Jonathan L Sessler.

Affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712- 0165, USA.

Abstract

Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimentaluse in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.

Keywords:

Texaphyrin, reactive oxygen species, anticancer activity, mechanism of action, zinc, platinum delivery, alpha and beta core emitters, superoxide dismutase, amyotrophic lateral sclerosis (ALS), Parkinson's Disease (PD), Alzheimer's Disease (AD), hydroquinones, chronic lymphocytic leukemia (CLL), Gd-oxalate-Gd bridging interactions, NAD levels.



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Article Details

Volume: 11
Issue Number: 2
First Page: 222
Last Page: 232
Page Count: 11
DOI: 10.2174/187152011795255894
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