Does More MnSOD Mean More Hydrogen Peroxide?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Does More MnSOD Mean More Hydrogen Peroxide?



Anti-Cancer Agents in Medicinal Chemistry, 11(2): 178-180.

Author(s): Lee Ann MacMillan-Crow and John P Crow.

Affiliation: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences 325 Jack Stephens Drive, Biomedical Building I, 323D, Little Rock, AR 72205.

Abstract

Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.

Keywords:

MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 11
Issue Number: 2
First Page: 178
Last Page: 180
Page Count: 3
DOI: 10.2174/187152011795255939
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science