Targeted Therapies in Metastatic Melanoma: Toward a Clinical Breakthrough?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Targeted Therapies in Metastatic Melanoma: Toward a Clinical Breakthrough?



Anti-Cancer Agents in Medicinal Chemistry, 10(9): 661-665.

Author(s): Fanny Julia, Luc Thomas, Charles Dumontet and Stephane Dalle.

Affiliation: Unit of Dermatology, Centre Hospitalier Lyon Sud, Chemin du grand revoyet, 69495 Pierre Benite Cedex, France.

Abstract

Metastatic melanoma is a very aggressive cancer. Dacarbazine has been considered as the standard therapy for decades. Due to a better understanding of melanoma cells signalling and immunological response, new targeted therapies are now proposed. The efficency of these new drugs needs to be confirmed by on larger clinical trials. Ipilimumab (anti-CTLA4 monoclonal antibody) and V600-E- B-raf inhibitor have shown encouraging results, while c-KIT and MEK inhibitors are currently under evaluation. These recently published data shed the light on melanoma management. We review here the latest development of these molecules and the current perspectives in the treatment of metastatic melanoma.

Keywords:

Melanoma, targeted therapy, ipilimumab, c-KIT inhibitor, B-raf inhibitor.



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Article Details

Volume: 10
Issue Number: 9
First Page: 661
Last Page: 665
Page Count: 5
DOI: 10.2174/187152010794479834
Price: $58
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