STAT3 as a Therapeutic Target for Glioblastoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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STAT3 as a Therapeutic Target for Glioblastoma



Anti-Cancer Agents in Medicinal Chemistry, 10(7): 512-519.

Author(s): Yan Liu, Chenglong Li and Jiayuh Lin.

Affiliation: Center for Childhood Cancer, Department of Pediatrics, College of Medicine, The Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA.

Abstract

Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor. Accordingly, recent studies have been focused on the aberrant signal transduction pathways in glioblastoma. Many patient derived primary glioblastomas and cell lines express constitutively activated signal transducers and activators of transcription 3 (STAT3). Here we focused on the recent progresses regarding to the roles of STAT3 in glioblastoma and glioblastoma stem cells (GBM-SCs), the dysregulation of STAT3 in glioblastoma, and targeting STAT3 for glioblastoma therapy.

Keywords:

Cytokine, glioblastoma, glioblastoma stem cells, growth factor, STAT3, STAT3 inhibitor, Recurrence, phosphorylated, proliferation, ONCOGENE, lymphomas, dimerizable, Tyrosine 705, chemical carcinogen, dephosphorylating, phenomenon, transmembrane, neurosphere, controversial, astrocytes, tumorigenesis, Peroxisome, dysregulatio, PTEN, Aspirin, Tocilizumab, Neutralizing.



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Article Details

Volume: 10
Issue Number: 7
First Page: 512
Last Page: 519
Page Count: 8
DOI: 10.2174/187152010793498636
Price: $58
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