Obesity Modulation - The Role in Carcinogenesis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Obesity Modulation - The Role in Carcinogenesis



Anti-Cancer Agents in Medicinal Chemistry, 10(6): 481-490.

Author(s): Ioannis Legakis and Kostantinos Syrigos.

Affiliation: Henry Dunant” Hospital 33 Alimousion Street, Thision, 11851 Athens, Greece.

Abstract

Obesity has been recognized as an important risk factor for many serious medical conditions. The association of obesity with an increased risk of many cancers is of enormous economic importance to the health industry.The metabolic syndrome and visceral obesity have an increasing prevelance and incidence in the general population.The actual prevelance of the metabolic syndrome is 24% in US population and between 24.6% and 30.9% in Europe. Recent evidence from epidemiologic and basic research studies, as well as clinical and intervention studies, supports the emerging hypothesis that metabolic syndrome may be an important etiologic factor for the onset of cancer. In addition, increased body weight has recently been shown to be associated with an increased risk of cancers at multiple specific sites. The close interaction between cancer cells and adipocytes is an intriguing issue in tumor biology. In nowdays, several metabolic markers are implicated in the development and progression of several malignancies. This review describes the emerging data concerning the role of metabolic markes in tumor cell growth and relates them to their future clinical prospects.

Keywords:

Metabolic syndrome, insulin-like growth factors, leptin, adiponectin, ghrelin, carcinogenesis, Obesity, cancer, hyperinsulinemia, Insulin, cardiovascular disease, adipokines, interleukin-6, tumor necrosis factor-α, apoptosis, EDTA, Adipose tissue, diabetes, body mass index, colorectal cancer, benign prostatic hyperplasia, breast cancer, Angiogenesis, diabetic retinopathy, benign prostatic hypertrophy, testosterone, estradiol, dihydrotestosterone, dehydroepiandrosterone sulfate, colonocyte cell proliferation, human hepatoma cells, Cancer Anorexia, anorexia, chronic obstructive pulmonary disease, Cachexia.



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Article Details

Volume: 10
Issue Number: 6
First Page: 481
Last Page: 490
Page Count: 10
DOI: 10.2174/1871520611009060481
Price: $58
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