Immunotherapy of Malignant Gliomas Using Autologous and Allogeneic Tissue Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Immunotherapy of Malignant Gliomas Using Autologous and Allogeneic Tissue Cells



Anti-Cancer Agents in Medicinal Chemistry, 10(6): 462-470.

Author(s): F. M. Hofman, A. Stathopoulos, C. A. Kruse, T. C. Chen and V EJC Schijns.

Affiliation: Departments of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.

Abstract

Immunotherapy of brain tumors is rapidly emerging as a potential clinical option [1-3]. The quality and magnitude of immune responses evoked by the new generation anti-tumor vaccines is in general highly dependent on the source or choice of peptide antigens, and as well, a suitable immunopotentiator. Poorly immunogenic antigens, such as those present in tumor cell lysates, may not reliably provide stimulation like recombinant or DNA-encoded protein antigens might be expected to. In addition, the efficacy of the vaccine may depend on inherent counteracting measures of the tumor which dampen immune surveillance and immune effector activity triggered by immunization [4]. Our body has many means of limiting an immune response to our own (self) proteins. In particular, patients with gliomas exhibit a broad suppression of cell-mediated immunity [5-8]. Unfortunately, for most tumor vaccines the induction of local or systemic immune effector cells does not necessarily translate into objective clinical responses or increased survival [9]. Here we review immunotherapeutic approaches against gliomas and recent pre-clinical and clinical initiatives based on cellular or active immunization of the patients immune system using autologous and allogeneic tissues or cultured cells. Available evidence shows that single modality cancer therapies likely remain suboptimal. Combination regimens targeting the immune system at multiple coordinated levels must be developed, and possibly combined with strategies to inhibit immune suppressive factors if significant clinical benefit is to be achieved.

Keywords:

Astrocytoma, allogeneic, biotherapy, brain tumor, CTL, glioma, immunotherapy, immunization, Malignant Gliomas, brain tumors, anti-tumor vaccines, immune surveillance, immune response, cell-mediated immunity, Glioblastoma multiforme, radiation, chemotherapy, pancytopenia, alkylating agent temozolomide, Coley's Toxins, tumor-specific cytotoxic T cells, class I Major Histocompatibility Complex, CD8-positive cytotoxic T cells, CD4 T cells, natural killer (NK) cells, Effector T Cells, T lymphocytes, Tumor Associated Antigens, glioma-associated antigens, real time polymerase chain reactions (qRT-PCR), tenascin, gp240, Antigen Presenting Cells, Dendritic cells, Dendritic Cell Vaccines, interferon (IFN)-α, Granulocyte macrophage-colony stimulating factor, toll-like receptor, CpG-oligonucleotide, K562 cells, IL-4-secreting fibroblasts, tumor-infiltrating immune cells, renal carcinoma, DNA-encoded protein antigens, Classical vaccines, tumor antigens, leukapheresis, synthetic CpG motifs, RNA oligonucleotides, oncolytic viruses, immunosuppression, immunosuppressive glucocorticoids, transforming growth factor (TGF)-β, interleukin, Vascular Endothelial Growth Factor, indoleamine 2,3, dioxgenase, T cell receptor, cytomegalovirus-specific T cells.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 10
Issue Number: 6
First Page: 462
Last Page: 470
Page Count: 9
DOI: 10.2174/1871520611009060462
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science