Novel Therapeutic Agents Against Cancer Stem Cells of Chronic Myeloid Leukemia

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Novel Therapeutic Agents Against Cancer Stem Cells of Chronic Myeloid Leukemia



Anti-Cancer Agents in Medicinal Chemistry, 10(2): 111-115.

Author(s): Yaoyu Chen, Cong Peng, Con Sullivan, Dongguang Li and Shaoguang Li.

Affiliation: University of Massachusetts Medical School, Department of Medicine, 364 Plantation Street, Worcester,MA 01605, USA.

Abstract

Chronic myeloid leukemia (CML) is induced by the BCR-ABL oncogene, a product of Philadelphia (Ph) chromosome. The BCR-ABL kinase inhibitor imatinib is a standard treatment for Ph+ leukemia, and has been shown to induce a complete hematologic and cytogenetic response in most chronic phrase CML patients. However, imatinib does not cure CML, and one of the reasons is that imatinib does not kill leukemia stem cells (LSCs) in CML both in vitro and in vivo. Recently, several new targets or drugs have been reported to inhibit LSCs in cultured human CD34+ CML cells or in mouse model of BCR-ABL induced CML, including an Alox5 pathway inhibitor, Hsp90 inhibitors, omacetaxine, hedgehog inhibitor and BMS-214662. Specific targeting of LSCs but not normal stem cell is a correct strategy for developing new anti-cancer therapies in the future.

Keywords:

BCR-ABL, leukemic stem cells, CML, therapeutic agents.



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Article Details

Volume: 10
Issue Number: 2
First Page: 111
Last Page: 115
Page Count: 5
DOI: 10.2174/187152010790909326
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