Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines



Anti-Cancer Agents in Medicinal Chemistry, 10(10): 769-776.

Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, Marcio S. Soares, Andre Lucio F. Sarria, Joao B. Fernandes, Maria Fatima G.F. Silva, Paulo Cezar Vieira, Pannee Pakkong, Gabriela M. Almeida, M. Helena Vasconcelos, Maria S.J. Nascimento and Madalena MM Pinto.

Affiliation: CEQUIMED-UP - Centro de Estudos de Quimica Medicinal, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal.

Abstract

Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.

Keywords:

Anticancer, apoptosis, breast adenocarcinoma, cell cycle arrest, limonoids, melanoma, non-small lung cancer, triterpenes, MCF-7, NCI-H460, NMR, Growth Assay, SRB, HDFC.



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Article Details

Volume: 10
Issue Number: 10
First Page: 769
Last Page: 776
Page Count: 8
DOI: 10.2174/187152010794728620
Price: $58
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