Targeting Focal Adhesion Kinase in Neuroblastoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Targeting Focal Adhesion Kinase in Neuroblastoma

Anti-Cancer Agents in Medicinal Chemistry, 10(10): 714-721.

Author(s): Lauren Gillory and Elizabeth A Beierle.

Affiliation: Department of Surgery, University of Alabama, Birmingham, 1600 7th Avenue South, ACC Room 300, Birmingham, AL 35233.


Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis. We have demonstrated FAK expression in human neuroblastoma cell lines and tumors, and have shown that FAK is important for neuroblastoma tumor cell viability. We have also demonstrated that FAK inhibition through a number of different methods results in decreased neuroblastoma survival both in vitro and in vivo. The current review addresses the merit of further exploring FAK inhibition as a novel treatment for neuroblastoma.


C4, FAK, neuroblastoma, NVP-TAE226, Y15, Cellular Adhesion, VEGFR, MHC, NCAM, MYCN, SKP, chloropyramine hydrochloride, tumor.

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Article Details

Volume: 10
Issue Number: 10
First Page: 714
Last Page: 721
Page Count: 8
DOI: 10.2174/187152010794728684
Price: $58

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