E-Pub Articles Ahead of Print ::: Anti-Cancer Agents in Medicinal Chemistry

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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E-Pub Articles Ahead of Print

Polo-like Kinase 1-targeting Chitosan Nanoparticles Suppress the Progression of Hepatocellular Carcinoma


Dongzhi Wang, Renan Chang, Gang Wang, Baoying Hu, Yong Qiang and Zhong Chen.


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Colorectal, Prostate and Pancreas Human Cancers Targeted Bioassay-guided Isolations and Characterization of Chemical Constituents from Tephrosia apollinea


Loiy Elsir A. Hassan, Muhammad Adnan Iqbal, Saad S. Dahham, Yasser M. Tabana, Mohamed B. Khadeer Ahamed and Amin MS Abdul Majid.


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Human cancer cell line based approach of 1,3,4-thiadiazole and its fused ring: A comprehensive review


Vinit Raj, Amit Rai and Sudipta Saha.


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Novel [1,2,4] Triazol [4,3-a] pyridine Derivatives as Potential Selective c-Met Inhibitors with Improved Pharmacokinetic Properties


Junjun Zhao, Shaohua Gou, Xiaobing Zhang, Yan Liang and Lei Fang.


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Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv


Qi Li, Yan Zhang, Junling Shi, Yilin Wang, Haobin Zhao, Dongyan Shao, Qingsheng Huang, Hui Yang and Mingling Jin.


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Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents


Andrea Ilaria Zotti, Elena Di Gennaro, Angela Corvino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Giuseppe Cirino, Fiorentina Roviezzo, Manuela Terranova-Barberio, Federica Iannelli, Giuseppe Caliendo, Vincenzo Santagada, Ferdinando Fiorino, Alfredo Budillon and Beatrice Severino.


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Docking and QSAR Studies of Aryl-valproic Acid Derivatives to Identify Antiproliferative Agents Targeting the HDAC8


Heidy Martínez-Pacheco, Guillermo Ramírez-Galicia, Midalia Vergara-Arias, Jürg Gertsch, Jonathan Manuel Fragoso-Vázquez, David Méndez-Luna, AL Abujamra, Cabrera-Pérez Laura Cristina, Rosales-Hernández Martha Cecilia, I Mendoza-Lujambio and José Correa-Basurto.


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The Warburg Effect and the Hallmarks of Cancer


Laurent Schwartz, Claudiu T. Supuran and Khalid O Alfarouk.


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Bortezomib Enhances the Antitumor Effects of Interferon-β Gene Transfer on Melanoma Cells


Úrsula Amaranta Rossi, Liliana María Elena Finocchiaro and Gerardo Claudio Glikin.


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ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice


Reshma Mahima Reji, SiddikUzzaman and Berlin Grace VM.


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4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies


Ri-Zhen Huang, Shi-Xian Hua, Cai-Yi Wang, Ying-Ming Pan, Jian-Mei Qin, Zhan-Yu Ding, Ye Zhang and Heng-Shan Wang.


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FLT3 Inhibitors in the Management of Acute Myeloid Leukemia


Elisabetta Zappone, Marzia Defina, Lara Aprile, Alessandro Gozzetti, Giulia Bartalucci and Monica Bocchia.


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2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth


Chunying Wu, Xizhen Wang, Nicholas Tomko, Junqing Zhu, William R. Wang, Jinle Zhu, Yanming Wang and Robert G Salomon.


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Dehydroleucodine Induces a TP73-dependent Transcriptional Regulation of Multiple Cell Death Target Genes in Human Glioblastoma Cells


Edward A Ratovitski.


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The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review


Yusha`u Shu`aibu Baraya, Kah Keng Wong and Nik Soriani Yaacob.


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Enzyme-Driven Chemo-and Radiation-Therapy with 12 Pyrimidine Nucleoside Analogs Not Yet in the Clinic


Sheldon Greer, Tieran Han, Cristina Dieguez, Nicola McLean, Rafael Saer, Isildinha Reis, Joe Levi and Victor E Marquez.


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Design and Synthesis of 4-substituted Quinazolines as Potent EGFR Inhibitors with Anti-breast Cancer Activity


Marwa Ahmed and Naja Magdy.


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Thiosemicarbazone Derivative Induces in vitro Apoptosis in Metastatic PC-3 Cells via Activation of Mitochondrial Pathway


Saravana Kumar Sinniah, Kong Wai Tan, Seik Weng Ng and Kae Shin Sim.


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Synthesis and Anti-cancer Activity of 3-substituted Benzoyl-4-substituted Phenyl-1Hpyrrole Derivatives


Xiaoping Zhan, Weixi Qin, Shuai Wang, Kai Zhao, Yuxuan Xin, Yaolin Wang, Qi Qi and Zhenmin Mao.


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TGF-β Signal Transduction in Pancreatic Carcinoma Cells is Sensitive to Inhibition by the Src Tyrosine Kinase Inhibitor AZM475271


Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert and Hendrik Ungefroren.


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Curcumin Targets Circulating Cancer Stem Cells by Inhibiting Self-Renewal Efficacy in Non-Small Cell Lung Carcinoma


Sheefa Mirza, Aakanksha Vasaiya, Hemangini Vora, Nayan Jain and Rakesh Rawal.


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Discovery of Potent Bruton’s Tyrosine Kinase Inhibitors Using Ligand Based Modeling


Wafa A. Mera, Malek Alzihlif, Mutasem O. Taha and Mohammad A Khanfar.


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Synthetic Mono/di-halogenated Coumarin Derivatives and Their Anticancer Properties


Kabange Kasumbwe, Katharigatta N. Venugopala, Viresh Mohanlall and Bharti Odhav.


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99mTc-HYNIC-D4 Peptide: A New Small Radiolabeled Peptide for Non Small Cell Lung Tumor Targeting


Mona Hadad, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr.


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Recent Advancements In 1, 4-Disubstituted 1H-1,2,3-Triazoles As Potential Anticancer Agents


Kashmiri Lal and Pinki Yadav.


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Antiproliferative and Apoptotic Effect of Dendrosomal Curcumin Nanoformulation in P53 Mutant and Wide-Type Cancer Cell Lines


Maryam Montazeri, Younes Pilehvar-Soltanahmadi, Mina Mohaghegh, Alireza Panahi, Samaneh Khodi, Nosratollah Zarghami and Majid Sadeghizadeh.


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Targeted therapy towards cancer – A perspective


Sean L Kitson, Vincenzo Cuccurullo, Andrea Ciarmiello and Luigi Mansi.


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Bruton Kinase Inhibitors in Chronic Lymphocytic Leukemia


Alessandro Gozzetti, Veronica Candi, Corrado Zuanelli Brambilla, Giulia Papini, Alberto Fabbri and Monica Bocchia.


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Evaluation of melatonin effect on human breast cancer stem cells using a three-dimensional growth method of mammospheres


Juliana Ramos Lopes, Mayume da Silva Kavagutti, Felipe Arthur Faustino Medeiros and Debora Aparecida Pires De Campos Zuccari.


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Design and Synthesis of NO-releasing Betulinic Acid Derivatives as Potential Anticancer Agents


Jinhong Liu, Zifei Zhu, Jia Tang, Qinghua Lin, Li Chen and Jianbo Sun.


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A 3D-QSAR Study on Betulinic Acid Derivatives as Anti-Tumor Agents and the Synthesis of Novel Derivatives for Modeling Validation


Weimin Ding, Sheng Zhang, Meixuan Zhu, Shaoming Wang, Tao Xu, Haijing Qu, Tao Yu, Xiufeng Yan and Yang Wang.


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Metastatic cell dormancy and re-activation: an overview on series of molecular events critical for cancer relapse


Györgyi Műzes and Ferenc Sipos.


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Preclinical and clinical studies of chidamide (CS055/HBI-8000), an orally available subtype-selective HDAC inhibitor for cancer therapy


Shuai Gao, Xiaoyang Li, Jie Zang, Wenfang Xu and Yingjie Zhang.


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Coumarin Derivatives as Anti-inflammatory and Anticancer Agents


Vidhya Thomas, D Giles, P M Basavarajaswamy Guru, Amit Kumar Das and Avani Patel.


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New poly(3-hydroxybutyrate) microparticles with paclitaxel sustained release for intraperitoneal administration


A.P. Bonartsev, A.L. Zernov, S.G. Yakovlev, I.I. Zharkova, V.L. Myshkina, T.K. Mahina, G.A. Bonartseva, N.V. Andronova, G.B. Smirnova, J.A. Borisova, M.S. Kalishjan, K.V. Shaitan and HM Treshalina.


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Development on PEG-modified Poly (Amino Acid) Copolymeric Micelles for Delivery of Anticancer Drug


Zhimei Song, Peizong Deng, Fangfang Teng, Feilong Zhou, Wenxiao Zhu and Runliang Feng.


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Docetaxel-loaded Bovine Serum Albumin Nanoparticles Conjugated Docosahexaenoic Acid for Inhibiting Lung Cancer Metastasis to Bone


Yuangang Zu, Yan Hu, Xueying Yu and Shougang Jiang.


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Design and Green Synthesis of Thieno[2,3-d]pyrimidine Analogues as Potential Antiproliferative Agents


Rupinder Kaur Gill, Virender Kumar, Mahendra Bishnoi, Kamalendra Yadav, Kanthi Kiran Kondepudi and Jitender Bariwal.


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Application of GA-MLR for QSAR Modeling of the Arylthioindole Class of Tubulin Polymerization Inhibitors as Anticancer Agents


Shahin Ahmadi and Elnaz Habibpour.


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The Role of Tumor Suppressor DLC-1: Far From Clear


Xu Liu, Yao-Jie Pan, Jun-Nian Zheng and Dong-Sheng Pei.


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Second Generation Proteasome Inhibitors in Multiple Myeloma


Alessandro Gozzetti, Giulia Papini, Veronica Candi, Corrado Zuanelli Brambilla, Santina Sirianni and Monica Bocchia.


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Therapeutic Use of Brentuximab Vedotin In Cd30+ Hematologic Malignancies


Alberto Fabbri, Emanuele Cencini, Alessandro Gozzetti, Luana Schiattone and Monica Bocchia.


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Sesamol Induces Apoptosis by Altering Expression of Bcl-2 and Bax Proteins and Modifies Skin Tumor Development in Balb/c Mice


Indu Pal Kaur, Tranum Kaur, Rishi Bhardwaj, Parneet Kaur Deol, Vandita Kakkar, Kim Vaiphei and SN Sanyal.


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NF-κB Signaling Pathway Inhibitors as Anticancer Drug Candidates


Maria Leticia De Castro Barbosa, Raissa Alves da Conceição, Aline Guerra Manssour Fraga, Barbara Dias Camarinha, Gabriela Cristina de Carvalho Silva, Antonio Gilcler Ferreira Lima, Elisama Azevedo Cardoso and Viviane de Oliveira Freitas Lione.


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Hybrid Benzoxazole-Coumarin Compounds Induce Death Receptor-Mediated Switchable Apoptotic and Necroptotic Cell Death on HN-5 Head and Neck Cancer Cell Line


Sahar Yaghmaei, Parichehr Ghalayani, Siamak Salami, Farahnaz Nourmohammadian, Soheila Kohestanimobarhan and Vahideh Imeni.


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Preclinical Toxicity Evaluation of Paclitaxel Biopolymer Formulation


Nadezhda Pavlovna Ermakova, Anton Pavlovich Bonartsev, Anton Lavrentievich Zernov, Olga Ivanovna Konyaeva, Natalia Yurievna Kulbachevskaya, Irina Borisovna Merkulova, Tatiana Vladimirovna Abramovac, Vera Andreevna Chaley, Sergey Georgievich Yakovlev, Garina Alexandrovna Bonartseva, Konstantin Valdemarovich Shaitan and Vladimir Mikhailovich Bukhman.


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Natural Compounds a Weapon to Ameliorate Breast cancer Cells: A Review


Ruchi Singh Thakur and Bharti Ahirwar.


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Retinoic acid Signaling in P19 Stem Cell Differentiation


Jyotshna Kanungo.


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Synthesis, Characterization, Anticancer and Antibacterial Activity of Some Novel Pyrano[2,3-d]pyrimidinone Carbonitrile Derivatives


Oluwole Aremu, Kaalin Gopaul, Pramod Nanasaheb Kadam, Moganavelli Singh, Chunderika Mocktar, Parvesh Singh and Neil Anthony Koorbanally.


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Y-shaped folic acid-conjugated PEG-PCL copolymeric micelles for delivery of curcumin


Runliang Feng, Wenxia Zhu, Wei Chu, Fangfang Teng, Ning Meng, Peizong Deng and Zhimei Song.


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Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors


Zafer Asım Kaplancıklı, Mehlika Dilek Altıntop, Özlem Atlı, Belgin Sever, Merve Baysal, Halide Edip Temel, Fatih Demirci and Ahmet Özdemir.


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Protective Effect of Perindopril on Tumor Progression and Angiogenesis in Animal Model of Breast Cancer


Snehal S. Patel and Surender Nakka.


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Phytochemical Analysis with Antioxidant and Cytotoxicity Studies of the Bioactive Principles from Zanthoxylum Capense (Small Knobwood)


Olusola Bodede, Shakira Shaik, Moganavelli Singh and Roshila Moodley.


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Construction of An Anticancer Fusion Peptide (ACFP) Derived from Milk Proteins and An Assay of Anti-ovarian Cancer Cells in vitro


Yide Qin, Juan Zhou, Wenxiao Zhang, Xue Yang, Jing Wang, Cai Wei, Fang Gu and Ting Lei.


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Triple Negative Breast Cancer: A Tale of Two Decades


Arwa Mohammed Ali, Jawaher Ali Ansari, Nashwa Mohammed AbdelAziz, Waleed Aabozeed, Ahmed Warith, Khalid Alsaleh and Jean-Marc Nabholtz.


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A Facile and Microwave-assisted Rapid Synthesis of 2-Arylamino-4-(3′-indolyl)- thiazoles as Apoptosis Inducing Cytotoxic Agents


Dalip Kumar, Mukund P. Tantak, Dipanwita Das Mukherjee, Anil Kumar and Gopal Chakrabarti.


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The Effects of 1,3,5-trisubstituted Indole Derivatives on Cell Growth, Apoptosis and MMP-2/9 mRNA Expression of MCF-7 Human Breast Cancer Cells


Filiz Bakar, Zuhal Kilic-Kurt, Mehmet Gokhan Caglayan and Sureyya Olgen.


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9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis


Wen-Tsan Chang, Yao Fong, Shih-Chang Chuang, Chon-Kit Chou, Han-Lin Chou, Chun-Feng Yang, Chih-Hua Tseng, Yeh-Long Chen and Chien-Chih Chiu.


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Ester of Quinoxaline-7-carboxylate 1,4-di-N-oxide as Apoptosis Inductors in K-562 Cell Line: An in vitro, QSAR and DFT study


Gildardo Rivera-Sánchez, Sergio Andrade-Ochoa, Manolo S. Ortega Romero, Isidro Palos, Antonio Monge and Luvia Enid Sánchez-Torres.


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Synthesis, Molecular Docking Study and in vitro Anticancer Activity of Tetrazole Linked Benzochromene Derivatives


Sridevi Gorle, Suresh Maddila, Surya N. Maddila, Kovashnee Naicker, Moganavelli Singh, Parvesh Singh and Sreekantha B Jonnalagadda.


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Glucose Oncometabolism of Esophageal Cancer


Jason S. Hochwald and Jianliang Zhang.


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Physico-chemical and Biological Evaluation of Flavonols: Fisetin, Quercetin and Kaempferol Alone and Incorporated in beta Cyclodextrins


Danciu Corina, Florina Bojin, Rita Ambrus, Delia Muntean, Codruta Soica, Virgil Paunescu, Mirabela Cristea, Iulia Pinzaru and Cristina Dehelean.


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Hydroxy Cinnamic Acid Derivatives as Partial PPARγ Agonists: In silico Studies, Synthesis and Biological Characterization Against Chronic Myeloid Leukemia Cell Line (K562)


Hardik Joshi, Kavita Marulkar, Vikram Gota and C S Ramaa.


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The use of Azoles Containing Natural Products in Cancer Prevention and Treatment: An Overview


Nasimudeen R. Jabir, Chelapram K. Firoz, Ashish Bhushan, Shams Tabrez and Mohammad A Kamal.


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Copper(II) Complexes with Saccharinate and Glutamine as Antitumor Agents: Cytoand Genotoxicity in Human Osteosarcoma Cells


J.F. Cadavid-Vargas, I.E. León, S.B. Etcheverry, E. Santi, M.H. Torre and AL Di Virgilio.


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1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity


Guoqing Wei, Hui Chen, Fangyuan Nie, Xiaofeng Ma and Hezhong Jiang.


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Nano-Hydroxyapatite Doped with Ho-166 as Drug Delivery System for Bone Cancer Therapy


Franciana Maria Rosa da Silva, Julio Cezar de Almeida Junior, Elizabeth Eugênio de Mello Oliveira, Marta de Souza Albernaz, Alexandre Malta Rossi and Ralph Santos-Oliveira.


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Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging.


Fiorella Carla Tesán, Mariano Portillo, Diego Martinel-Lamas, Vanina Araceli Medina, María Jimena Salgueiro and Marcela Zubillaga.


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15,16-dihydrotanshinone I induces apoptosis and inhibits the proliferation, migration of human osteosarcoma cell line 143B in vitro


Xuepeng Chen, Qihong Li, Yan He, Hongjiang Du, Zhajun Zhan, Hong zhao, Jiejun Shi, Qingsong Ye and Ji'an Hu.


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Research Progress on the Antitumor Effects of Rhein: Literature Review


Chao Wu, Hongyan Cao, Hua Zhou, Lin Sun, Jingui Xue, Jianyuan Li, Yanqin Bian, Runfei Sun, Shu Dong, Ping Liu and Mingyu Sun.


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Synthesis and Anticancer Study of novel 4H-Chromen Derivatives


Xiaolin Lu, Gaochao Dong, Ying Zheng, Chao Zhang, Yang Qiu, Tao Lu and Xiang Zhou.


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Effects of Epirubicin and Cisplatin against 4T1 Breast Cancer Cells are Enhanced by Myrtucommulone-A


Kenan izgi, Banu iskender, Cagri Sakalar, Aslıhan Arslanhan, Esra Hilal Yüksek, Esra Hizar and Halit Canatan.


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Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1


Adisorn Ratanaphan, Tidarat Nhukeaw, Khwanjira Hongthong and Paul J Dyson.


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Epidrugs in the Immunotherapy of Cutaneous and Uveal Melanoma


Mario Venza, Maria Visalli, Teresa Catalano, Concetta Beninati, Diana Teti and Isabella Venza.


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8-bromo-7-methoxychrysin reversed M2 polarization of tumor-associated macrophages induced by liver cancer stem-like cells


Shuwen Sun, Yinghong Cui, Kaiqun Ren, Meifang Quan, Zhenwei Song, Hui Zou, Duo Li, Yu Zheng and Jianguo Cao.


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Regulatory Approaches to Non-clinical Reproductive Toxicity Testing of Anti-Cancer Drugs.


Georg Schmitt and Paul Barrow.


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Sodium Selenite as an Anti-Cancer Agent


Boguslaw Lipinski.


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Preparation and Evaluation of in vitro Self-assembling HSA Nanoparticles for Cabazitaxel


Na Qu, Yating Sun, Jing Xie and Lesheng Teng.


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Thiazolidinone constraint combretastatin analogs as novel antitubulin agents: Design, synthesis, biological evaluation and docking studies


Sahil Sharma, Manish Kumar Gupta, Ajit Kumar Saxena and Preet Mohinder Singh Bedi.


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Autophagy Inhibits Apoptosis Induced by agrocybe aegerita Lectin in Hepatocellular Carcinoma


Wei Liu, Guojun Yu, Wenhui Yu, Xiangdong Ye, Yanxia Jin, Alok Shrestha, Qing Yang and Hui Sun.


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Fe3O4 Nanoparticles Mediated Synthesis of Novel Isatin-Pyrimidinone Hybrid Molecules as Antioxidant and Cytotoxic Agents


Srinubabu Maddela, Ajitha Makula and N Jayarambabu.


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New Approaches to Photodynamic Therapy from Type I, II and III to Type IV Using One or More Photons


Kathrin M. Scherer, Roger H. Bisby, Stanley W. Botchway and Anthony W Parker.


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Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines


Van-Son Nguyen, Ling Shi, Sheng-Chun Wang and Qiu-An Wang.


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Plant Derived Inhibitor Sulforaphane in Combinatorial Therapy Against Therapeutically Challenging Pancreatic Cancer


Shabir Ahmad Ganai, Romana Rashid, Ehsaan Abdullah and Mohammad Altaf.


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Cetuximab immunoliposomes enhances delivery of 5-FU to skin squamous carcinoma cells


Raquel Petrilli, Josimar O. Eloy, Renata F. V. Lopez and Robert J Lee.


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Radiopharmaceuticals in Tumor Hypoxia Imaging: A Review Focused on Medicinal Chemistry Aspects


Pablo Cabral and Hugo Cerecetto.


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Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine


Giuseppe Losurdo, Mariabeatrice Principi, Bruna Girardi, Maria Pricci, Michele Barone, Enzo Ierardi and Alfredo Di Leo.


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Breast Cancer: Current Molecular Therapeutic Targets and New Players


Siddavaram Nagini.


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L-Canavanine Potentiates Cytotoxicity of Chemotherapeutic Drugs in Human Breast Cancer Cells


Agustina D. R. Nurcahyanti and Michael Wink.


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Radiolabeled Nanoparticles for Cancer Diagnosis and Therapy


Jacek Koziorowski, Adina E. Stanciu, Vanessa Gómez-Vallejo and Jordi Llop.


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Effects of Anticancer Drugs in Reproductive Parameters of Juvenile Male Animals and Role of Protective Agents


Juliana Elaine Perobelli.


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Design and Synthesis of Coumarin Derivatives as Novel PI3K Inhibitors


Ma Chen-Chen and Zhao-Peng Liu.


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