E-Pub Articles Ahead of Print ::: Anti-Cancer Agents in Medicinal Chemistry

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Articles Ahead of Print

Anticancer Activities of New N-hetaryl-2-cyanoacetamide Derivatives Incorporating 4,5,6,7-Tetrahydrobenzo[b]thiophene Moiety


Magda F. Mohamed, Yasmin M Attia, Samia A. Shouman and Ismail A Abdelhamid.


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Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision


Nare Sahakyan, Amir Haddad, Shye Richardson, Valery Forcha-Etieundem, Lee Christopher, Hanan Alharbi and Robert Campbell.


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Immune Checkpoints Aberrations and Malignant Mesothelioma: Assessment of Prognostic Value and Evaluation of Therapeutic Potentials


Hadeer Mohamed, Mostafa Eltobgy and Omar Abdel-Rahman.


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Inhibition of TGF-β Signaling in Tumor Cells by Small Molecule Src Family Kinase Inhibitors


Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnerta and Hendrik Ungefroren.


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Cytokine Status of Serum in Ovarian Cancer Patients with Different Tumor Neoadjuvant Chemotherapy Response


Inna I. Antoneeva, Tatyana V. Abakumova, Dinara R. Dolgova, Tatyana P. Gening, Sabina S. Pirmamedova, Dinara F. Myasnikova and Snezhanna O Gening.


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Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2)Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines


Ali Aydın, Şengül Aslan Korkmaz, Veysel Demir and Şaban Tekin.


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Targeting Leptin as a Therapeutic Strategy against Ovarian Cancer Peritoneal Metastasis


Xiao Wei, Yi Liu, Cheng Gong, Teng Ji, Xiaoshui Zhou, Taoran Zhang, Dongyi Wan, Sen Xu, Ping Jin, Xin Yang, Xiaoting Li, Ding Ma, Zongyuan Yang and Qinglei Gao.


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Hybrid Benzoxazole-Coumarin Compounds Induce Death Receptor-Mediated Switchable Apoptotic and Necroptotic Cell Death on HN-5 Head and Neck Cancer Cell Line


Sahar Yaghmaei, Parichehr Ghalayani, Siamak Salami, Farahnaz Nourmohammadian, Soheila Koohestanimobarhan and Vahideh Imeni.


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Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4-phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells


Rodríguez-Fonseca Rolando Alberto, Sixto-López Yudibeth, Fragoso-Vázquez M. Jonathan, Flores-Mejía Raúl, Cabrera-Pérez Laura Cristina, Vázquez-Moctezuma Ismael, Rosales-Hernández Martha Cecilia, Bello Martiniano, M. Martínez-Archundia, Trujillo-Ferrara José Guadalupe, Becerra-Martínez Elvia and Correa-Basurto José.


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Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines


Ceren E. Oturanel, İsmail Kıran, Özge Özşen, Gülşen A. Çiftçi and Özlem Atlı.


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Nano-Delivery in Pediatric Tumors: Looking Back, Moving Forward


Marta Colletti, Virginia Di Paolo, Angela Galardi, Giuseppe Maria Milano, Angela Mastronuzzi, Franco Locatelli and Angela Di Giannatale.


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Double Edge Sword Behavior of Carbendazim: A Potent Fungicide With Anti-Cancer Therapeutic Properties


Karan Goyal, Ajay Sharma, Ridhima Arya, Rohit Sharma, Girish K. Gupta and Anil K Sharma.


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The Effect of A Hexanoic Acid Linker Insertion on the Pharmacokinetics and Tumor Targeting Properties of the Melanoma Imaging Agent 99mTc-HYNIC-cycMSH


Vania Teixeira, Marcelo Fernández, Natalia Oddone, Xiuli Zhang, Fabio Gallazzi, Hugo Cerecetto, Juan Pablo Gambini, Williams Porcal, Pablo Cabral and Thomas P Quinn.


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Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies


Haixing Guan, Yongli Du, Weiwei Han, Jingkang Shen and Qunyi Li.


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Major Highlights of the CAR-TCR Summit, Boston, 2016


Vita Golubovskaya, Robert Berahovich, Shirley Xu, Hizkia Harto and Lijun Wu.


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Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives


Khurshid Ahmad, Mohd Kalim A. Khan, Mohammad Hassan Baig, Mohd Imran and Girish Kumar Gupta.


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Novel Hybrid Molecules on the Basis of Steroids and (5Z,9Z)-Tetradeca-5,9-dienoic Acid: Synthesis, Anti-Cancer Studies and Human Topoisomerase I Inhibitory Activity


Vladimir A. D`yakonov, Lilya U. Dzhemileva, Regina A. Tuktarova, Svetlana R. Ishmukhametova, Milyausha M. Yunusbaeva, Ilfir R. Ramazanova and Usein M Dzhemilev.


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Cytotoxic and Chemopreventive Effects of Gemin D Against Different Mutagens Using In Vitro and In Vivo Assays


Cristiene Costa Carneiro, Aroldo Vieira Moraes-Filho, Amanda Silva Fernandes, Suzana Costa Santos, Daniela Melo Silva and Lee Chen Chen.


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Anti-cancer Agents in Medicinal Chemistry Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-boswellic Acid and their Cytotoxic Activity


Tao Li, Peihong Fan, Yaqing Ye, Qian Luo and Hongxiang Lou.


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Improved Immunogenicity Against a Her2/neu-derived Peptide by Employment of a Pan HLA DR-binding Epitope and CpG in a BALB/c Mice Model


Sahar Tahaghoghi-hajghorbani, Jalil Tavakkol-Afshari, Mahmoud Reza Jaafari, Haniyeh Ghaffari-Nazari, Elham Masoumi and Seyed Amir Jalali.


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Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme


Konstantinos Daniilides, Nikolaos Lougiakis, Thomas Evangelidis, Ioannis K. Kostakis, Nicole Pouli, Panagiotis Marakos, Emmanuel Mikros, Alexios-Leandros Skaltsounis, Stéphane Bach, Blandine Baratte, Sandrine Ruchaud, Valia Karamani, Alexandra Papafotika, Savvas Christoforidis, Orestis Argyros, Eva Kouvari and Constantin Tamvakopoulos.


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Polo-like Kinase 1-targeting Chitosan Nanoparticles Suppress the Progression of Hepatocellular Carcinoma


Dongzhi Wang, Renan Chang, Gang Wang, Baoying Hu, Yong Qiang and Zhong Chen.


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Colorectal, Prostate and Pancreas Human Cancers Targeted Bioassay-guided Isolations and Characterization of Chemical Constituents from Tephrosia apollinea


Loiy Elsir A. Hassan, Muhammad Adnan Iqbal, Saad S. Dahham, Yasser M. Tabana, Mohamed B. Khadeer Ahamed and Amin MS Abdul Majid.


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Human cancer cell line based approach of 1,3,4-thiadiazole and its fused ring: A comprehensive review


Vinit Raj, Amit Rai and Sudipta Saha.


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Novel [1,2,4] Triazol [4,3-a] pyridine Derivatives as Potential Selective c-Met Inhibitors with Improved Pharmacokinetic Properties


Junjun Zhao, Shaohua Gou, Xiaobing Zhang, Yan Liang and Lei Fang.


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Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv


Qi Li, Yan Zhang, Junling Shi, Yilin Wang, Haobin Zhao, Dongyan Shao, Qingsheng Huang, Hui Yang and Mingling Jin.


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Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents


Andrea Ilaria Zotti, Elena Di Gennaro, Angela Corvino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Giuseppe Cirino, Fiorentina Roviezzo, Manuela Terranova-Barberio, Federica Iannelli, Giuseppe Caliendo, Vincenzo Santagada, Ferdinando Fiorino, Alfredo Budillon and Beatrice Severino.


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Docking and QSAR Studies of Aryl-valproic Acid Derivatives to Identify Antiproliferative Agents Targeting the HDAC8


Heidy Martínez-Pacheco, Guillermo Ramírez-Galicia, Midalia Vergara-Arias, Jürg Gertsch, Jonathan Manuel Fragoso-Vázquez, David Méndez-Luna, AL Abujamra, Cabrera-Pérez Laura Cristina, Rosales-Hernández Martha Cecilia, I Mendoza-Lujambio and José Correa-Basurto.


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Bortezomib Enhances the Antitumor Effects of Interferon-β Gene Transfer on Melanoma Cells


Úrsula Amaranta Rossi, Liliana María Elena Finocchiaro and Gerardo Claudio Glikin.


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ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice


Reshma Mahima Reji, SiddikUzzaman and Berlin Grace VM.


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4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies


Ri-Zhen Huang, Shi-Xian Hua, Cai-Yi Wang, Ying-Ming Pan, Jian-Mei Qin, Zhan-Yu Ding, Ye Zhang and Heng-Shan Wang.


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FLT3 Inhibitors in the Management of Acute Myeloid Leukemia


Elisabetta Zappone, Marzia Defina, Lara Aprile, Alessandro Gozzetti, Giulia Bartalucci and Monica Bocchia.


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2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth


Chunying Wu, Xizhen Wang, Nicholas Tomko, Junqing Zhu, William R. Wang, Jinle Zhu, Yanming Wang and Robert G Salomon.


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Dehydroleucodine Induces a TP73-dependent Transcriptional Regulation of Multiple Cell Death Target Genes in Human Glioblastoma Cells


Edward A Ratovitski.


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The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review


Yusha`u Shu`aibu Baraya, Kah Keng Wong and Nik Soriani Yaacob.


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Design and Synthesis of 4-substituted Quinazolines as Potent EGFR Inhibitors with Anti-breast Cancer Activity


Marwa Ahmed and Naja Magdy.


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Thiosemicarbazone Derivative Induces in vitro Apoptosis in Metastatic PC-3 Cells via Activation of Mitochondrial Pathway


Saravana Kumar Sinniah, Kong Wai Tan, Seik Weng Ng and Kae Shin Sim.


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Synthesis and Anti-cancer Activity of 3-substituted Benzoyl-4-substituted Phenyl-1Hpyrrole Derivatives


Xiaoping Zhan, Weixi Qin, Shuai Wang, Kai Zhao, Yuxuan Xin, Yaolin Wang, Qi Qi and Zhenmin Mao.


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TGF-β Signal Transduction in Pancreatic Carcinoma Cells is Sensitive to Inhibition by the Src Tyrosine Kinase Inhibitor AZM475271


Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert and Hendrik Ungefroren.


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Curcumin Targets Circulating Cancer Stem Cells by Inhibiting Self-Renewal Efficacy in Non-Small Cell Lung Carcinoma


Sheefa Mirza, Aakanksha Vasaiya, Hemangini Vora, Nayan Jain and Rakesh Rawal.


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99mTc-HYNIC-D4 Peptide: A New Small Radiolabeled Peptide for Non Small Cell Lung Tumor Targeting


Mona Hadad, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr.


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Recent Advancements In 1, 4-Disubstituted 1H-1,2,3-Triazoles As Potential Anticancer Agents


Kashmiri Lal and Pinki Yadav.


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Antiproliferative and Apoptotic Effect of Dendrosomal Curcumin Nanoformulation in P53 Mutant and Wide-Type Cancer Cell Lines


Maryam Montazeri, Younes Pilehvar-Soltanahmadi, Mina Mohaghegh, Alireza Panahi, Samaneh Khodi, Nosratollah Zarghami and Majid Sadeghizadeh.


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Bruton Kinase Inhibitors in Chronic Lymphocytic Leukemia


Alessandro Gozzetti, Veronica Candi, Corrado Zuanelli Brambilla, Giulia Papini, Alberto Fabbri and Monica Bocchia.


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Evaluation of melatonin effect on human breast cancer stem cells using a three-dimensional growth method of mammospheres


Juliana Ramos Lopes, Mayume da Silva Kavagutti, Felipe Arthur Faustino Medeiros and Debora Aparecida Pires De Campos Zuccari.


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A 3D-QSAR Study on Betulinic Acid Derivatives as Anti-Tumor Agents and the Synthesis of Novel Derivatives for Modeling Validation


Weimin Ding, Sheng Zhang, Meixuan Zhu, Shaoming Wang, Tao Xu, Haijing Qu, Tao Yu, Xiufeng Yan and Yang Wang.


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Metastatic cell dormancy and re-activation: an overview on series of molecular events critical for cancer relapse


Györgyi Műzes and Ferenc Sipos.


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Preclinical and clinical studies of chidamide (CS055/HBI-8000), an orally available subtype-selective HDAC inhibitor for cancer therapy


Shuai Gao, Xiaoyang Li, Jie Zang, Wenfang Xu and Yingjie Zhang.


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Development on PEG-modified Poly (Amino Acid) Copolymeric Micelles for Delivery of Anticancer Drug


Zhimei Song, Peizong Deng, Fangfang Teng, Feilong Zhou, Wenxiao Zhu and Runliang Feng.


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Docetaxel-loaded Bovine Serum Albumin Nanoparticles Conjugated Docosahexaenoic Acid for Inhibiting Lung Cancer Metastasis to Bone


Yuangang Zu, Yan Hu, Xueying Yu and Shougang Jiang.


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Design and Green Synthesis of Thieno[2,3-d]pyrimidine Analogues as Potential Antiproliferative Agents


Rupinder Kaur Gill, Virender Kumar, Mahendra Bishnoi, Kamalendra Yadav, Kanthi Kiran Kondepudi and Jitender Bariwal.


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Application of GA-MLR for QSAR Modeling of the Arylthioindole Class of Tubulin Polymerization Inhibitors as Anticancer Agents


Shahin Ahmadi and Elnaz Habibpour.


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The Role of Tumor Suppressor DLC-1: Far From Clear


Xu Liu, Yao-Jie Pan, Jun-Nian Zheng and Dong-Sheng Pei.


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Second Generation Proteasome Inhibitors in Multiple Myeloma


Alessandro Gozzetti, Giulia Papini, Veronica Candi, Corrado Zuanelli Brambilla, Santina Sirianni and Monica Bocchia.


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Therapeutic Use of Brentuximab Vedotin In Cd30+ Hematologic Malignancies


Alberto Fabbri, Emanuele Cencini, Alessandro Gozzetti, Luana Schiattone and Monica Bocchia.


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Sesamol Induces Apoptosis by Altering Expression of Bcl-2 and Bax Proteins and Modifies Skin Tumor Development in Balb/c Mice


Indu Pal Kaur, Tranum Kaur, Rishi Bhardwaj, Parneet Kaur Deol, Vandita Kakkar, Kim Vaiphei and SN Sanyal.


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NF-κB Signaling Pathway Inhibitors as Anticancer Drug Candidates


Maria Leticia De Castro Barbosa, Raissa Alves da Conceição, Aline Guerra Manssour Fraga, Barbara Dias Camarinha, Gabriela Cristina de Carvalho Silva, Antonio Gilcler Ferreira Lima, Elisama Azevedo Cardoso and Viviane de Oliveira Freitas Lione.


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Preclinical Toxicity Evaluation of Paclitaxel Biopolymer Formulation


Nadezhda Pavlovna Ermakova, Anton Pavlovich Bonartsev, Anton Lavrentievich Zernov, Olga Ivanovna Konyaeva, Natalia Yurievna Kulbachevskaya, Irina Borisovna Merkulova, Tatiana Vladimirovna Abramovac, Vera Andreevna Chaley, Sergey Georgievich Yakovlev, Garina Alexandrovna Bonartseva, Konstantin Valdemarovich Shaitan and Vladimir Mikhailovich Bukhman.


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Retinoic acid Signaling in P19 Stem Cell Differentiation


Jyotshna Kanungo.


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Synthesis, Characterization, Anticancer and Antibacterial Activity of Some Novel Pyrano[2,3-d]pyrimidinone Carbonitrile Derivatives


Oluwole Aremu, Kaalin Gopaul, Pramod Nanasaheb Kadam, Moganavelli Singh, Chunderika Mocktar, Parvesh Singh and Neil Anthony Koorbanally.


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Y-shaped folic acid-conjugated PEG-PCL copolymeric micelles for delivery of curcumin


Runliang Feng, Wenxia Zhu, Wei Chu, Fangfang Teng, Ning Meng, Peizong Deng and Zhimei Song.


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Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors


Zafer Asım Kaplancıklı, Mehlika Dilek Altıntop, Özlem Atlı, Belgin Sever, Merve Baysal, Halide Edip Temel, Fatih Demirci and Ahmet Özdemir.


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Protective Effect of Perindopril on Tumor Progression and Angiogenesis in Animal Model of Breast Cancer


Snehal S. Patel and Surender Nakka.


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Phytochemical Analysis with Antioxidant and Cytotoxicity Studies of the Bioactive Principles from Zanthoxylum Capense (Small Knobwood)


Olusola Bodede, Shakira Shaik, Moganavelli Singh and Roshila Moodley.


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Construction of An Anticancer Fusion Peptide (ACFP) Derived from Milk Proteins and An Assay of Anti-ovarian Cancer Cells in vitro


Yide Qin, Juan Zhou, Wenxiao Zhang, Xue Yang, Jing Wang, Cai Wei, Fang Gu and Ting Lei.


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Triple Negative Breast Cancer: A Tale of Two Decades


Arwa Mohammed Ali, Jawaher Ali Ansari, Nashwa Mohammed AbdelAziz, Waleed Aabozeed, Ahmed Warith, Khalid Alsaleh and Jean-Marc Nabholtz.


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The Effects of 1,3,5-trisubstituted Indole Derivatives on Cell Growth, Apoptosis and MMP-2/9 mRNA Expression of MCF-7 Human Breast Cancer Cells


Filiz Bakar, Zuhal Kilic-Kurt, Mehmet Gokhan Caglayan and Sureyya Olgen.


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9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis


Wen-Tsan Chang, Yao Fong, Shih-Chang Chuang, Chon-Kit Chou, Han-Lin Chou, Chun-Feng Yang, Chih-Hua Tseng, Yeh-Long Chen and Chien-Chih Chiu.


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Ester of Quinoxaline-7-carboxylate 1,4-di-N-oxide as Apoptosis Inductors in K-562 Cell Line: An in vitro, QSAR and DFT study


Gildardo Rivera-Sánchez, Sergio Andrade-Ochoa, Manolo S. Ortega Romero, Isidro Palos, Antonio Monge and Luvia Enid Sánchez-Torres.


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Physico-chemical and Biological Evaluation of Flavonols: Fisetin, Quercetin and Kaempferol Alone and Incorporated in beta Cyclodextrins


Danciu Corina, Florina Bojin, Rita Ambrus, Delia Muntean, Codruta Soica, Virgil Paunescu, Mirabela Cristea, Iulia Pinzaru and Cristina Dehelean.


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Hydroxy Cinnamic Acid Derivatives as Partial PPARγ Agonists: In silico Studies, Synthesis and Biological Characterization Against Chronic Myeloid Leukemia Cell Line (K562)


Hardik Joshi, Kavita Marulkar, Vikram Gota and C S Ramaa.


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The use of Azoles Containing Natural Products in Cancer Prevention and Treatment: An Overview


Nasimudeen R. Jabir, Chelapram K. Firoz, Ashish Bhushan, Shams Tabrez and Mohammad A Kamal.


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1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity


Guoqing Wei, Hui Chen, Fangyuan Nie, Xiaofeng Ma and Hezhong Jiang.


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15,16-dihydrotanshinone I induces apoptosis and inhibits the proliferation, migration of human osteosarcoma cell line 143B in vitro


Xuepeng Chen, Qihong Li, Yan He, Hongjiang Du, Zhajun Zhan, Hong zhao, Jiejun Shi, Qingsong Ye and Ji'an Hu.


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Research Progress on the Antitumor Effects of Rhein: Literature Review


Chao Wu, Hongyan Cao, Hua Zhou, Lin Sun, Jingui Xue, Jianyuan Li, Yanqin Bian, Runfei Sun, Shu Dong, Ping Liu and Mingyu Sun.


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Synthesis and Anticancer Study of novel 4H-Chromen Derivatives


Xiaolin Lu, Gaochao Dong, Ying Zheng, Chao Zhang, Yang Qiu, Tao Lu and Xiang Zhou.


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Regulatory Approaches to Non-clinical Reproductive Toxicity Testing of Anti-Cancer Drugs.


Georg Schmitt and Paul Barrow.


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Sodium Selenite as an Anti-Cancer Agent


Boguslaw Lipinski.


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Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine


Giuseppe Losurdo, Mariabeatrice Principi, Bruna Girardi, Maria Pricci, Michele Barone, Enzo Ierardi and Alfredo Di Leo.


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Effects of Anticancer Drugs in Reproductive Parameters of Juvenile Male Animals and Role of Protective Agents


Juliana Elaine Perobelli.


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