Naphthalimides as Anticancer Agents: Synthesis and Biological Activity

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Naphthalimides as Anticancer Agents: Synthesis and Biological Activity

Anti-Cancer Agents in Medicinal Chemistry, 1(3): 237-255.

Author(s): M. F. Brana and A Ramos.

Affiliation: Departamento de Quimica Organica y Farmaceutica, Facultad de Ciencias Experimentales, Universidad San Pablo-CEU, Monteprincipe. Boadilla del Monte, 28668-Madrid, Spain.


Naphthalimides are a class of compounds with high antitumor activity upon a variety of murine and human tumor cells. These compounds bind to DNA by intercalation of the chromophore and two of them, mitonafide and amonafide, were used in clinical trials. The therapeutic properties of these lead drugs were improved by designing bisintercalating agents. One of these, elinafide, showed intense in vitro and in vivo activity and is currently being used in clinical trials against solid tumors. In this paper, the history of elinafide is described.

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Article Details

Volume: 1
Issue Number: 3
First Page: 237
Last Page: 255
Page Count: 19
DOI: 10.2174/1568011013354624
Price: $58

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