Protein-Protein Interactions: Lessons Learned

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Protein-Protein Interactions: Lessons Learned

Anti-Cancer Agents in Medicinal Chemistry, 2(2): 311-330.

Author(s): S. K. Sharma, T. M. Ramsey and K W Bair.

Affiliation: Oncology Department, Novartis Institute for Biomedical Research, 556 Morris Avenue,Summit, NJ 07901, USA


Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer. This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.


Protein-Protein Interactions, Hydrophobic Interactions, Tyrosine Kinase Receptors, Calmodulin, histocompatibility complex, ADP-ribosylation factor.

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Article Details

Volume: 2
Issue Number: 2
First Page: 311
Last Page: 330
Page Count: 20
DOI: 10.2174/1568011023354191
Price: $58

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