Structure-Based Design of Novel Anti-Cancer Agents TargetingAurora Kinases

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Structure-Based Design of Novel Anti-Cancer Agents TargetingAurora Kinases

Anti-Cancer Agents in Medicinal Chemistry, 3(1): 25-34.

Author(s): Daruka Mahadevan, David J. Bearss and Hariprasad Vankayalapati.

Affiliation: Arizona Cancer Center, University of Arizona, 1515, N. Campbell Ave., Tucson, AZ, 85724, USA.


Aurora kinases are a family of mitotic serine-threonine kinases (S / T kinases), that functions as a class of novel oncogenes and are over-expressed in several solid tumors including breast, ovary, prostate, pancreas and colorectal cancer. To validate human ARK1 (Aurora2, STK15, HsAIRK1) as a drugable target in pancreatic cancer, we undertook a structure-based approach to design specific inhibitors utilizing homology modeling, affinity docking and an in vitro kinase assay in an iterative process. In this review, we discuss the biology, rationale for targeting and approaches taken to inhibit this family of protein kinases, implicated in dysregulated chromosome segregation and cytokinesis.


Anti-Cancer Agents, Novel, argetingAurora, chromosome segregation, cytokinesis.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 3
Issue Number: 1
First Page: 25
Last Page: 34
Page Count: 10
DOI: 10.2174/1568011033353524
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science