Hypoxic Radiosensitizers and Hypoxic Cytotoxins in Radiation Oncology

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Hypoxic Radiosensitizers and Hypoxic Cytotoxins in Radiation Oncology



Anti-Cancer Agents in Medicinal Chemistry, 3(5): 364-374.

Author(s): Martin Weinmann, Stefan Welz and Michael Bamberg.

Affiliation: Klinik fur Radioonkologie, Universitat Tubingen,Hoppe-Seyler Str. 3, D-72076 Tubingen, Germany.

Abstract

Tumor hypoxia is a major constraint for the tumor treatment by radiotherapy. The efficacy of ionizing radiation directly relies on adequate oxygen tensions. Furthermore, hypoxia is related to malignant progression, increased invasion, angiogenesis and an increased risk of metastases formation. Two different types of strategies can be used to overcome the problem of hypoxia-mediated radioresistance. The first strategy encompasses a variety of different methods to improve the tumor oxygenation during radiotherapy. The second strategy tries to target hypoxia as a relatively unique feature of tumor tissue by means of drugs, which are activated under hypoxic conditions and act as hypoxic radiosensitizers or hypoxic cytotoxins. This article reviews in brief the clinical experience with different generations of hypoxic radiosensitizers and hypoxic cytotoxins, which have been applied in combination with primary radiotherapy during the last three decades.

Keywords:

hypoxia, radiotherapy, hypoxic sensitizer, hypoxic cytotoxins, combined treatment.



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Article Details

Volume: 3
Issue Number: 5
First Page: 364
Last Page: 374
Page Count: 11
DOI: 10.2174/1568011033482350
Price: $58
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