Disruption of Cell Death Signaling in Cancer: Impact on Disease Prognosis and Response to Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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5 - Year: 2.849

Disruption of Cell Death Signaling in Cancer: Impact on Disease Prognosis and Response to Therapy

Anti-Cancer Agents in Medicinal Chemistry, 3(5): 319-326.

Author(s): Dilek Guner, Claus Belka and Peter T Daniel.

Affiliation: Molecular Hematology and Oncology, Robert Rossle Klinik, Charite, Campus Buch, Lindenberger Weg80, 13125 Berlin, Germany.


Disruption of cell cycle and apoptosis signaling pathways are key events during tumorigenesis, tumor progression and development of resistance against anticancer therapies. Thus, the analysis of functional alterations within these signaling cascades is of utmost importance for the understanding of resistance mechanisms, clinical outcome and risk-adapted treatment strategies. Key signaling pathways involved in the treatment resistance include the p53 / p14ARF signaling complex and the mitochondrial apoptosis machinery. Apart from the direct genetic events, these signaling cascades are subject to epigenetic modulations implied by the tumor microenvironment.


apoptosis, cell cycle, cancer, prognosis, resistance to therapy.

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Article Details

Volume: 3
Issue Number: 5
First Page: 319
Last Page: 326
Page Count: 8
DOI: 10.2174/1568011033482369
Price: $58
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