Antifolates - Past, Present and Future

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Current: 2.722
5 - Year: 2.849

Antifolates - Past, Present and Future

Anti-Cancer Agents in Medicinal Chemistry, 4(5): 405-410.

Author(s): Aleem Gangjee and Hiteshkumar D Jain.

Affiliation: Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.


This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.


thymidylate synthase (ts), dihydrofolate reductase (dhfr), antifolates, classical, nonclassical, inhibitors.

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Article Details

Volume: 4
Issue Number: 5
First Page: 405
Last Page: 410
Page Count: 6
DOI: 10.2174/1568011043352803
Price: $58

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