Antitumor Pharmacology - Quo Vadis ?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Antitumor Pharmacology - Quo Vadis ?



Anti-Cancer Agents in Medicinal Chemistry, 4(5): 389-391.

Author(s): Christian Bailly, Jean-Marc Barret and Anna Kruczynski.

Affiliation: Institut de Recherches Pierre Fabre, Institut de Sciences et Technologies du Medicament de Toulouse, 3rue des Satellites, 31140 Toulouse, France.

Abstract

In recent years, efforts have been made to improve the selectivity of anti-cancer agents via the targeting of cancer-specific proteins or signalisation pathways. Novel anticancer drugs inhibiting defined kinases, the proteasome, and selected growth factor receptors for examples have been developed with success for a few cancer types. But in parallel to these novel “soft” drugs, conventional “hard” cytotoxic molecules targeting DNA, topoisomerases or tubuline remain extensively used to treat solid tumors. This letter evokes the utility and limitations of the two drug categories and comments on new directions of the antitumor pharmacology taken to improve the efficacy of cancer chemotherapy and the development of new molecules.

Keywords:

antitumor pharmacology, anti-cancer agents, signalisation pathways, kinases, proteasome, soft drugs, cytotoxic molecules.



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Article Details

Volume: 4
Issue Number: 5
First Page: 389
Last Page: 391
Page Count: 3
DOI: 10.2174/1568011043352849
Price: $58
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