Histone Deacetylase Inhibitors: Latest Developments, Trends and Prospects

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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5 - Year: 2.849

Histone Deacetylase Inhibitors: Latest Developments, Trends and Prospects

Anti-Cancer Agents in Medicinal Chemistry, 5(5): 529-560.

Author(s): O. Moradei, C. R. Maroun, I. Paquin and A Vaisburg.

Affiliation: Director, Medicinal Chemistry, MethyGene Inc., Canada.


Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are enzymes that catalyze the deacetylation and acetylation of lysine residues located in the NH2 terminal tails of histones and non-histone proteins. Perturbation of this balance is often observed in human cancers and inhibition of HDACs has emerged as a novel therapeutic strategy against cancer. To date, more that 30 groups, academic and industrial, are involved in research related to these target enzymes. Over the past year, dozens of research papers and patent applications describing new HDAC inhibitors belonging to different structural classes have been disclosed. The present review highlights the latest developments in design and synthesis of HDAC inhibitors - potential anti-cancer drugs.


histone deacetylase (hdac), histone deacetylase (hdac) inhibitor, cancer, tumor, enzyme isoform, hydroxamate, tetrapeptide.

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Article Details

Volume: 5
Issue Number: 5
First Page: 529
Last Page: 560
Page Count: 32
DOI: 10.2174/1568011054866946
Price: $58
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