Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids

Anti-Cancer Agents in Medicinal Chemistry, 5(2): 173-182.

Author(s): C. Stevigny, C. Bailly and J Quetin-Leclercq.

Affiliation: Laboratoire de Pharmacognosie, Unite d;Analyse Chimique et Physico-Chimique des Medicaments, Universite Catholique de Louvain, UCL 72.30-CHAM, Av. E. Mounier 72, 1200 Bruxelles, Belgium.


Aporphinoids form an important group of plant secondary metabolites. Some of these compounds are used for a long time in traditional medicine for the treatment of various diseases, from benign syndromes to more severe illnesses. More than 500 aporphine alkaloids have been isolated from various plant families and many of these compounds display potent cytotoxic activities which may be exploited for the design of anticancer agents. Here we review the origin, biosynthesis, structure and cytotoxic properties of the prominent members of this class of compounds. Simple aporphinoids (boldine, dicentrine) as well as oxo-, pro- and dehydro-aporphines, and dimeric forms such as thalicarpine, are discussed here. Their mechanisms of action are not well known but DNA-manipulating enzymes such as polymerases and topoisomerases are among the most frequently cited targets for these benzylisoquinoline compounds. This review presents an updated view of the cytotoxic properties of the aporphinoids and their potential contribution to the development of anticancer agents.


aporphine alkaloids, aporphinoids, anticancer agents, natural products, cytotoxicity.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 5
Issue Number: 2
First Page: 173
Last Page: 182
Page Count: 10
DOI: 10.2174/1568011053174864
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science