Cisplatin Resistance and Transcription Factors

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Cisplatin Resistance and Transcription Factors

Anti-Cancer Agents in Medicinal Chemistry, 5(1): 15-27.

Author(s): Takayuki Torigoe, Hiroto Izumi, Hiroshi Ishiguchi, Yoichiro Yoshida, Mizuho Tanabe, Takeshi Yoshida, Tomonori Igarashi, Ichiro Niina, Tetsuro Wakasugi, Takuya Imaizumi, Yasutomo Momii, Michihiko Kuwano and Kimitoshi Kohno.

Affiliation: Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.


Cisplatin is one of the most potent and widely used anti-cancer agents in the treatment of various solid tumors. However, the development of resistance to cisplatin is a major obstacle in clinical treatment. Several mechanisms are thought to be involved in cisplatin resistance, including decreased intracellular drug accumulation, increased levels of cellular thiols, increased nucleotide excision-repair activity and decreased mismatch-repair activity. In general, the molecules responsible for each mechanism are upregulated in cisplatin-resistant cells; this indicates that the transcription factors activated in response to cisplatin might play crucial roles in drug resistance. It is known that the tumor-suppressor proteins p53 and p73, and the oncoprotein c-Myc, which function as transcription factors, influence cellular sensitivity to cisplatin. So far, we have identified several transcription factors involved in cisplatin resistance, including Y-box binding protein-1 (YB-1), CCAAT-binding transcription factor 2 (CTF2), activating transcription factor 4 (ATF4), zinc-finger factor 143 (ZNF143) and mitochondrial transcription factor A (mtTFA). Two of these-YB-1 and ZNF143-lack the high-mobility group (HMG) domain and can bind preferentially to cisplatin-modified DNA in addition to HMG domain proteins or DNA repair proteins, indicating that these transcription factors may also participate in DNA repair. In this review, we summarize the mechanisms of cisplatin resistance and focus on transcription factors involved in the genomic response to cisplatin.


atf4, cisplatin, c-myc, ctf2.

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Article Details

Volume: 5
Issue Number: 1
First Page: 15
Last Page: 27
Page Count: 13
DOI: 10.2174/1568011053352587
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

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