Genistein and its Synthetic Analogs as Anticancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Genistein and its Synthetic Analogs as Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry, 12(3): 271-281.

Author(s): Qing-Shan Li, Cui-Yun Li, Zi-Lin Li and Hai-Liang Zhu.

Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R.China.


Genistein, one of the predominant isoflavones derived from soybeans, has been shown beneficial effects in cancer prevention and treatment. There is an accumulating body of experimental evidences suggesting that genistein affects cancer progression by increasing apoptosis, inducing cell cycle arrest,modulating intracellular signaling pathways, and inhibiting invasion and metastasis of cancer cells. During last decade, many researchers have conducted extensive studies by synthesizing amounts of structurally-modified derivatives based on the isoflavone skeleton of genistein to enhance its anticancer activity, some analogs of which possess more potent activities of the prevention and/or treatment of various cancers. In this review, we summarized the current knowledge regarding anticancer effects,structure-activity relationships and action mechanisms of genistein and its synthesized analogs, which would be beneficial to the rational design of new genistein derivatives as anticancer drugs.


Akt, androgen, anticancer agents, apoptosis, cancer therapy, CDK, cell cycle, chemoprevention, genistein, isoflavone.

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Article Details

Volume: 12
Issue Number: 3
First Page: 271
Last Page: 281
Page Count: 11
DOI: 10.2174/187152012800228788
Price: $58

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