Impact of Oncogenic Protein Tyrosine Phosphatases in Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Impact of Oncogenic Protein Tyrosine Phosphatases in Cancer



Anti-Cancer Agents in Medicinal Chemistry, 12(1): 4-18.

Author(s): Serge Hardy, Sofi G. Julien and Michel L Tremblay.

Affiliation: McGill University, Goodman Cancer Centre 1160 Pine Avenue, Room 601 Montreal, QC, Canada H3A 1A3.

Abstract

Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that can exert both positive and negative effects on signaling pathways. They play dominant roles in setting the levels of intracellular phosphorylation downstream of many receptors including receptor tyrosine kinases and G protein-coupled receptors. As observed with kinases, deregulation of PTP activity can also contribute to cancer. This review will examine a broad array of PTP family members that positively affect oncogenesis in human cancer tissues. We will describe the PTP family, their biological significance in oncology, and how recent progress is being made to more effectively target specific PTPs. Finally, we will discuss the therapeutic implications of targeting these oncogenic PTPs in cancer.

Keywords:

Cancer, Inhibitors, dual-specificity phosphatases (DSPs), Oncogene, Protein tyrosine phosphatases, Phosphorylation, Tumor suppressor, G protein-coupled receptors (GPCRs), Amplification, Gynecological Cancers.



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Article Details

Volume: 12
Issue Number: 1
First Page: 4
Last Page: 18
Page Count: 15
DOI: 10.2174/187152012798764741
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