Ceramide Transfer Protein and Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Ceramide Transfer Protein and Cancer



Anti-Cancer Agents in Medicinal Chemistry, 11(9): 904-910.

Author(s): Luana Scheffer, Pralhada Rao Raghavendra, Jingjing Ma and Jairaj K Acharya.

Affiliation: National Cancer Institute, Laboratory of Cell&Developmental Signaling, Rm. 22-90 B, Bldg. 560, 1050 Boyle St., Frederick, MD 21702.

Abstract

Sphingolipids are important structural components of membranes, and play an equally important role in basic cellular processes as second messengers. Recently, sphingolipids are receiving increasing attention in cancer research. Ceramide is the central molecule that regulates sphingolipid metabolism forming the basic structural backbone of sphingolipids and the precursor of all complex sphingolipids. It is been proposed to be an important regulator of tumor cell death following exposure to stress stimuli. The increase or decrease of ceramide levels leading to change in sensitivity of cancer cells to stress stimuli provides support for a central role of ceramide signaling in cell death. In this review, we have focused on ceramide transfer protein (CERT) as a major regulator of ceramide flux in the cell.

Keywords:

Ceramide, Ceramide transfer protein, cancer, shingolipids, ER, CERT, LCB, DHS, phytosphingosine, ERK-MAPK, SCID, Rheostat.



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Article Details

Volume: 11
Issue Number: 9
First Page: 904
Last Page: 910
Page Count: 7
DOI: 10.2174/187152011797655087
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