Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma

Anti-Cancer Agents in Medicinal Chemistry, 11(4): 398-407.

Author(s): Surajit Karmakar, Subhasree Roy Choudhury, Naren L. Banik and Swapan K Ray.

Affiliation: Department of Pathology,Microbiology, and Immunology, University of South Carolina School of Medicine, Building 2, Room C11, 6439 Garners Ferry Road, Columbia, SC 29209, USA.


The medicinal properties of garlic (Allium sativum) have been well known and widely used since historical times. Garlic compounds have received increasing attention during the last few years due to their cancer chemopreventive properties. The anti-cancer activity of garlic-derived organosulfur compounds (OSCs) are extensively reported in many cancers but only a few in the pediatric tumor neuroblastoma, which warrants exploration of new therapy for its management. There are some recent reports suggesting that garlicderived OSCs cause cell cycle arrest, generate reactive oxygen species (ROS), activate stress kinases, and also stimulate the mitochondrial pathway for apoptosis in malignant neuroblastoma. The comprehensive mechanisms of anti-cancer action of OSCs still remain unclear and require more studies in neuroblastoma. This review is designed to highlight the known molecular mechanisms of anti-cancer actions of garlic-derived OSCs in neuroblastoma and as well as in several other cancers. Further studies should be conducted to establish the clinical expediency of garlic-derived OSCs for treatment of malignant neuroblastoma in humans.


Apoptosis, caspases, calpain, diallyl sufide, diallyl disulfide, neuroblastoma, stem cell transplantation, high-risk neuroblastomas, DNA fragmentation, pro-apoptotic molecules, DNase (ICAD), Apoptosis-inducing factor (AIF), phytochemicals.

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Article Details

Volume: 11
Issue Number: 4
First Page: 398
Last Page: 407
Page Count: 10
DOI: 10.2174/187152011795677553
Price: $58

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