Cellular Uptake and Organ Accumulation of Amphipolar Metallocorroles with Cytoprotective and Cytotoxic Properties

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Cellular Uptake and Organ Accumulation of Amphipolar Metallocorroles with Cytoprotective and Cytotoxic Properties



Anti-Cancer Agents in Medicinal Chemistry, 11(4): 380-384.

Author(s): Zoya Okun, Lana Kupershmidt, Moussa B. H. Youdim and Zeev Gross.

Affiliation: Schulich Faculty of Chemistry,Technion - Israel Institute of Technology, Haifa 32000, Israel.

Abstract

We report here an investigation that focuses on the organ distribution of metal complexes that are chelated by the amphipolar corrole whose macrocycle is decorated by two sulphonic acid head groups, which are emerging potential therapeutics against cancer (the cytotoxic Ga chelate) and diseases that are characterized by excessive production of ROS and RNS (the cytoprotective Mn and Fe derivatives). We show that the intraperitoneally injected fluorescent gallium(III) derivative accumulates in tissues sections of the kidney, liver, lung, heart, and pancreas. It also reaches the brain blood vessels, but does not cross the blood brain barrier. These findings are of prime importance for future in vivo studies on disease models, as they point toward a large utility of this kind of corrole chelates for treating cancer, neurodegenerative diseases characterized by “leaking BBB”, cardiovascular diseases and diabetes.

Keywords:

Imaging, oxidative stress, bioavailability, bio-distribution, corroles, cancer, diabetes, neurodegenerative diseases, metallocorroles, cell-internalizing motifs, of penicillin/streptomycin/nystatin, Minimum Essential Medium, paraformaldehyde solution, cholesterol biosynthesis, b cells (insulinoma).



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Article Details

Volume: 11
Issue Number: 4
First Page: 380
Last Page: 384
Page Count: 5
DOI: 10.2174/187152011795677535
Price: $58
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