Pancreatic Cancer in Obesity: Epidemiology, Clinical Observations, and Basic Mechanisms

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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5 - Year: 2.849

Pancreatic Cancer in Obesity: Epidemiology, Clinical Observations, and Basic Mechanisms



Anti-Cancer Agents in Medicinal Chemistry, 11(5): 470-478.

Author(s): Nicholas J. Zyromski and Patrick B White.

Affiliation: Department of Surgery, Indiana University School of Medicine, 535 Barnhill Drive, RT 130, Indianapolis, IN 46202, USA.

Abstract

Obesity, now a worldwide epidemic, causes myriad medical problems. One of the most significant obesity-related problems is the well-recognized relationship between obesity and various malignancies, including pancreatic cancer. Pancreatic cancer is a devastating disease – the annual death rate nearly approximates its incidence. While surgical extirpation provides the best chance at long term survival, systemic therapy is largely ineffective: even those patients undergoing successful operative resection have only approximately 20% 5-year survival. These poor outcomes are largely a consequence of poor understanding of tumor biology. Clearly, identification of novel treatment strategies is of paramount importance; investigation of pancreatic cancer biology from the novel aspect of obesity offers the potential to identify unique therapeutic targets. This manuscript reviews the epidemiology, clinical findings, and putative basic science mechanisms underlying obesity-related pancreatic cancer.

Keywords:

Pancreatic cancer, obesity, adipokines, tumor immunology, adiponectin, leptin, B-lymphocytes.



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Article Details

Volume: 11
Issue Number: 5
First Page: 470
Last Page: 478
Page Count: 9
DOI: 10.2174/187152011795677445
Price: $58
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