Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma



Anti-Cancer Agents in Medicinal Chemistry, 11(5): 442-447.

Author(s): Michael H Muders.

Affiliation: Institute of Pathology, University Hospital Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany.

Abstract

The Neuropilin receptors are increasingly recognized as receptors for vascular endothelial growth factors like VEGF-A and VEGF-C as well as other important growth factors like HGF and FGF in human vasculature and in tumor cells. More and more studies show an important role of Neuropilin in cancer biology suggesting that these transmembrane proteins might be an emerging target for new therapies in different subsets of cancer. Interestingly, blocking the adaptor protein GIPC1/Synectin that interacts with Neuropilin might be another interesting avenue for therapy. This review summarizes unfolding scientific data on these receptors and its interacting protein GIPC1/Synectin as molecular targets for therapy in pancreatic ductal adenocarcinoma.

Keywords:

GIPC1, neuropilin-1, neuropilin-2, pancreatic cancer, synectin, targeted therapy.



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Article Details

Volume: 11
Issue Number: 5
First Page: 442
Last Page: 447
Page Count: 6
DOI: 10.2174/187152011795677481
Price: $58
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