Aptamers: Potential Applications to Pancreatic Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Aptamers: Potential Applications to Pancreatic Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 11(5): 434-441.

Author(s): Kristy L. Rialon and Rebekah R White.

Affiliation: Department of Surgery, Duke University Medical Center, DUMC Box 103035, Durham, NC 27710, USA.

Abstract

There is an unquestionable need for more effective therapies for pancreatic cancer. Aptamers are single-stranded DNA or RNA oligonucleotide ligands whose 3-dimensional structures are dictated by their sequences. Aptamers have been generated against numerous purified protein targets using an iterative in vitro selection technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX). Several biochemical properties make them attractive tools for use in an array of biological research applications and as potential pharmacologic agents. Isolated aptamers may directly affect target protein function, or they may also be modified for use as delivery agents for other therapeutic cargo or as imaging agents. More complex selections, using whole cancer cells or tumor tissue, may simultaneously identify novel or unexpected targets and aptamers to inhibit them. This review summarizes recent advances in the field of aptamers and discusses aptamer targets that have relevance to pancreatic cancer.

Keywords:

Aptamer, cancer therapy, pancreatic cancer, RNA therapeutic, SELEX.



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Article Details

Volume: 11
Issue Number: 5
First Page: 434
Last Page: 441
Page Count: 8
DOI: 10.2174/187152011795677472
Price: $58
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