Does More MnSOD Mean More Hydrogen Peroxide?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Does More MnSOD Mean More Hydrogen Peroxide?

Anti-Cancer Agents in Medicinal Chemistry, 11(2): 178-180.

Author(s): Lee Ann MacMillan-Crow and John P Crow.

Affiliation: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences 325 Jack Stephens Drive, Biomedical Building I, 323D, Little Rock, AR 72205.


Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.


MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP.

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Article Details

Volume: 11
Issue Number: 2
First Page: 178
Last Page: 180
Page Count: 3
DOI: 10.2174/187152011795255939
Price: $58

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