Mechanisms of Drug Resistance to Vascular Endothelial Growth Factor (VEGF) Inhibitors

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Mechanisms of Drug Resistance to Vascular Endothelial Growth Factor (VEGF) Inhibitors

Anti-Cancer Agents in Medicinal Chemistry, 10(8): 593-600.

Author(s): Jahan Tavakoli and Jeanny B Aragon-Ching.

Affiliation: Division of Hematology and Oncology, George Washington University Medical Center, 2150 Pennsylvania Avenue, NW, Washington, DC 20037, USA.


Angiogenesis inhibitors have a major role in the treatment of varying cancers today. While originally thought to be independent of resistance, increasing data suggests varying mechanisms that bring about drug resistance, either intrinsically or through adaptation. The role of vascular endothelial growth factor single nucleotide polymorphisms (VEGF SNPs) in terms of therapeutic response and toxicity has increasingly been recognized, as well as its potential for contributing to drug resistance. This review will focus on theories, preclinical models, and clinical trials that help elucidate the mechanisms of resistance and clinical response to angiogenesis inhibitors.


Angiogenesis, angiogenesis inhibitors, polymorphisms, drug resistance, toxicity.

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Article Details

Volume: 10
Issue Number: 8
First Page: 593
Last Page: 600
Page Count: 8
DOI: 10.2174/187152010794473948
Price: $58
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