Liver Cancer Stem Cells as an Important Target in Liver Cancer Therapies

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Liver Cancer Stem Cells as an Important Target in Liver Cancer Therapies



Anti-Cancer Agents in Medicinal Chemistry, 10(2): 172-175.

Author(s): Gang-Ming Zou.

Affiliation: State Key Laboratory for Oncogene and Related Gene, Shanghai Cancer Institute, Shanghai Jiaotong University, 800 Dong Chuan Road, Wenxuan Medicine Bldg. Rm442.,Shanghai, 200240. PR. China.

Abstract

Hepatic cancer is one of most common cause of cancer-related death. Hepato-epithelial cancers are believed to originate from the malignant transformation of liver-resident stem/progenitor cells. Liver cancer stem cells have been characterized recently and the phenotype of liver cancer stem cells has been defined as CD133+ CD44+ cancer cells. Recently, it has been also demonstrated about the relevance of targeting liver cancer stem cells, due to cancer stem cells are related to cancer metastasis. These advances no doubt to bring the new strategy in liver cancer treatment and control in this disease. This review describes the current status and progress about cancer stem cell research in liver and discuss of the implications of these studies in new liver cancer treatment strategies.

Keywords:

CD133, CD44, CD90, IL-6, TGF-β.



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Article Details

Volume: 10
Issue Number: 2
First Page: 172
Last Page: 175
Page Count: 4
DOI: 10.2174/187152010790909263
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