Potential Targets for Improving Radiosensitivity of Breast Tumor-Initiating Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Potential Targets for Improving Radiosensitivity of Breast Tumor-Initiating Cells



Anti-Cancer Agents in Medicinal Chemistry, 10(2): 152-156.

Author(s): Wei Xu, Bisrat G. Debeb, Lara Lacerd and Wendy A Woodward.

Affiliation: Division of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd.Box 1202, 77030 Houston, Texas, USA.

Abstract

Recent studies have suggested that a specific small population of cells termed tumor-initiating cells (TICs) may be intrinsically resistant to therapy including radiation, and may therefore be the primary mediators of recurrence. Numerous targets are being explored using multiple approaches for their involvement in the self-renewal or survival as well as radioresistance of breast TICs. These studies will provide a broad range of compounds to be tested and to develop novel TIC radiosensitizers that will improve clinical outcome and decrease recurrence of cancer after radiation. In this review we will discuss recent efforts to identify and target these cells to selectively radiosensitize them with novel agents, as well as the TIC radiosensitizing potential of current therapies already in clinical use.

Keywords:

Breast cancer, Radiation, Cancer stem cells, Tumor-initiating cells.



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Article Details

Volume: 10
Issue Number: 2
First Page: 152
Last Page: 156
Page Count: 5
DOI: 10.2174/187152010790909362
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