Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

Anti-Cancer Agents in Medicinal Chemistry, 10(4): 283-292.

Author(s): Luca Ronconi, Donatella Aldinucci, Q. Ping Dou and Dolores Fregona.

Affiliation: Department of Chemical Sciences, University of Padova, Via Marzolo 1, Padova 35131, Italy.


In this review paper we aim at giving a detailed overview on our research work devoted to the design of gold-based anticancer agents. In particular, during the last decade, we have been developing some gold(III)-dithiocarbamato derivates showing outstanding in vitro and in vivo antitumor properties and reduced, or even no, systemic and renal toxicity, compared to the reference clinically-established anticancer drug cisplatin. Starting from the rationale behind our investigations, we here summarize the results achieved so far, focusing on the latest in-depth mechanistic studies that have recently provided insights into their mechanism of action, thus opening up new prospects for further pharmacological testing and, hopefully, to enter clinical trials.


Anticancer drug, Dithiocarbamate, Gold compounds, Metallodrug, Nephrotoxicity, Proteasome inhibitor, Reactive oxygen species (ROS), Thioredoxin reductase (TrxR).

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Article Details

Volume: 10
Issue Number: 4
First Page: 283
Last Page: 292
Page Count: 10
DOI: 10.2174/187152010791162298
Price: $58

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