Hepatocyte Growth Factor and Its Receptor Signalling Complex as Targets in Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


Download PDF Flyer




Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Hepatocyte Growth Factor and Its Receptor Signalling Complex as Targets in Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 10(1): 2-6.

Author(s): Tracey A. Martin and Wen G Jiang.

Affiliation: Metastasis&Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

Abstract

Hepatocyte growth factor (HGF) and its receptor, cMET, have become the focus on intense scrutiny since its discovery in the late 1980s [1, 2] as regards it role in cancer. HGF is now known to be a potent morphogen that can regulate tissue and organ regeneration and modulate cell morphology, it is a motogen that can stimulate cell motility and migration, and is a mitogen able to regulate cell growth and death and as an angiogenic factor [3]. HGF is can induce both angiogenesis and lymphangiogenesis [3a; 4]. That HGF and cMET have such a diversity of functions has led to intense interest in the clinical setting due to their potential in their prognostic aspect and therapeutic implications as imaging tools. This issue will focus on recent work that shows strong indications for the value of HGF and cMET in clinical settings.

Keywords:

Hepatocyte growth factor, cMET, angiogenesis, metastasis, imaging, cancer treatment.



Download Free Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 10
Issue Number: 1
First Page: 2
Last Page: 6
Page Count: 5
DOI: 10.2174/1871520611009010002
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science