Targeting Prostate Cancer Stem Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Targeting Prostate Cancer Stem Cells

Anti-Cancer Agents in Medicinal Chemistry, 9(10): 1105-1113.

Author(s): Francesco Crea, Lesley A. Mathews, William L. Farrar and Elaine M Hurt.

Affiliation: Laboratory of Cancer Prevention, NCI-Frederick, 1050 Boyles Street, Building 560, Room 21-81, USA.


Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.


Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin.

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Article Details

Volume: 9
Issue Number: 10
First Page: 1105
Last Page: 1113
Page Count: 9
DOI: 10.2174/187152009789735053
Price: $58
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