Agents Targeting Prostate Cancer Bone Metastasis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Agents Targeting Prostate Cancer Bone Metastasis

Anti-Cancer Agents in Medicinal Chemistry, 9(10): 1079-1088.

Author(s): Khalid S. Mohammad, Pierrick G. Fournier, Theresa A. Guise and John M Chirgwin.

Affiliation: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Walther C647, IUPUI, Indianapolis, IN 46202, USA.


Bone is the most common site for metastasis of advanced prostate cancers. Once housed in the skeleton, tumors are incurable and cause protracted morbidity, and bone metastases may contribute to mortality through unknown mechanisms. Bone provides a unique microenvironment whose local interactions with tumor cells offer novel targets for therapeutic interventions. Many standard cancer treatments cause bone loss, which may aggravate skeletal metastases, although this is preventable with approved agents. Improved bonetargeted treatments can decrease the serious skeletal morbidities associated with metastatic prostate cancer and may in the future improve overall survival. The development of such treatments requires preclinical evaluation in animal models of prostate cancer growth in bone.


Prostate cancer, bone, metastasis, osteolytic, osteoblastic, bisphosphonate, RANK ligand, endothelin, TGF-beta.

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Article Details

Volume: 9
Issue Number: 10
First Page: 1079
Last Page: 1088
Page Count: 10
DOI: 10.2174/187152009789735008
Price: $58

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