Cytotoxic Compounds in the Treatment of Castration-Resistant Prostate Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Cytotoxic Compounds in the Treatment of Castration-Resistant Prostate Cancer

Anti-Cancer Agents in Medicinal Chemistry, 9(10): 1040-1045.

Author(s): Patrick Lee and Jeanny B Aragon-Ching.

Affiliation: Division of Hematology and Oncology, George Washington University Medical Center, 2150 Pennsylvania Avenue, NW, Washington, DC 20037, USA.


Prostate cancer is the most common non-cutaneous cancer among men in the United States. Most will be diagnosed at an early stage, but a significant number will still develop metastatic castration resistant disease. Docetaxel has demonstrated improved quality of life and overall survival in metastatic castration-resistant prostate cancer but virtually all patients will ultimately become refractory to taxane therapy. Second-line options are limited and new effective chemotherapeutic agents or combinations are needed in this setting. This review will focus on cytotoxic compounds in clinical investigation either in combination with taxanes in the first or second-line setting and other novel compounds, such as platinums and microtubule-targeting agents that are in active clinical investigation.


Chemotherapy, platinum, docetaxel, microtubule-targeting agents, epothilones, prostate cancer.

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Article Details

Volume: 9
Issue Number: 10
First Page: 1040
Last Page: 1045
Page Count: 6
DOI: 10.2174/187152009789734991
Price: $58
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