Development of Small Molecular Probes for the Molecular Imaging of Apoptosis

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

Download PDF Flyer

Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 59 in Chemistry, Medicinal

Submit Abstracts Online Submit Manuscripts Online

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.722
5 - Year: 2.849

Development of Small Molecular Probes for the Molecular Imaging of Apoptosis

Anti-Cancer Agents in Medicinal Chemistry, 9(9): 986-995.

Author(s): Wenbin Zeng and Weimin Miao.

Affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.


Apoptosis, or programmed cell death, is an important physiologic process multicellular organisms use to maintain homeostasis by providing a means for elimination of redundant cells during development. Furthermore, cells that have become damaged or are defective undergo apoptosis to prevent disease. It is an important process involved in the etiology, pathogenesis, and response to therapy of a variety of diseases. Specific biochemical changes occur in cell or tissue undergoing apoptosis that offer potential targets for imaging tracers. There are a number of tracers that can be used to identify apoptotic cells, including morphological changes, caspase activation, and DNA fragmentation. In this article, the recent progresses of small molecular based probes for detecting apoptotic cells are reviewed. In addition, the traditional and modern imaging technologies which use to visualize these probes is also discussed.


Apoptosis, imaging, small molecular, cell death, probe.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 9
Issue Number: 9
First Page: 986
Last Page: 995
Page Count: 10
DOI: 10.2174/187152009789377763
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science