Tyrosinase Activated Melanoma Prodrugs

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Tyrosinase Activated Melanoma Prodrugs



Anti-Cancer Agents in Medicinal Chemistry, 9(7): 717-727.

Author(s): Samaila Jawaid, Tariq H. Khan, Helen M.I. Osborn and Nana Aba O Williams.

Affiliation: School of Pharmacy, University of Reading, Whiteknights, Reading, UK.

Abstract

Metastatic malignant melanoma remains a highly aggressive form of skin cancer for which no reliable methods for treatment exist. Given the increasing incidence of this cancer, considerable attention has focused on the development of new and improved methods for tackling this disease. Within this article, methods for treating melanoma are reviewed and discussed with particular attention focusing on prodrugs that are activated by the tyrosinase enzyme. This enzyme is up-regulated and is of elevated activity within malignant melanomas compared with healthy melanocytes, providing an ideal in-situ tool for the activation of melanoma prodrugs. By way of background to the prodrug strategies discussed within this review, the causes of melanoma, the enzymology of tyrosinase, and the chemistry of the biosynthetic pathways associated with melanogenesis are presented. Aspects of the design, mode of action, and biological profiles of key prodrugs that are activated by tyrosinase, and that show potential for the treatment of melanoma, are then presented and compared.

Keywords:

Melanoma, prodrug, tyrosinase, ortho, melanogenesis, metastasis.



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Article Details

Volume: 9
Issue Number: 7
First Page: 717
Last Page: 727
Page Count: 11
DOI: 10.2174/187152009789056886
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