Current Development of Pd(II) Complexes as Potential Antitumor Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Current Development of Pd(II) Complexes as Potential Antitumor Agents



Anti-Cancer Agents in Medicinal Chemistry, 9(3): 356-368.

Author(s): Enjun Gao, Cong Liu, Mingchang Zhu, Huakuan Lin, Qiong Wu and Lei Liu.

Affiliation: Chemistry Department, Nankai University, Tianjin, 300071, P.R. China.

Abstract

Research has proven that the most effective and widely used metal-containing chemotherapy anticancer drugs are cisplatin ([cis-PtCl2(NH3)2]) and many platinum complexes, however, these compounds have significant disadvantages including poor water solubility and serious side effects. Thus researches in order to overcome these shortcomings have never interrupted. Many non-platinum complexes have been synthesized and tested, in which some palladium complexes show significant antitumor activity in normal tumor cells and lower resistance of tumor cells to clinical treatments as well as lower side effects. Mononuclear palladium complexes with aromatic N-containing ligands, amino acid ligands, S-donor ligands, and P-containing ligands have respective qualities and properties due to the different structures and properties of the ligands; some dinuclear palladium complexes possess interesting steric structures and good antitumor activity; a try to modify natural medicines with Pd2+ leads the research to a new route. In this review, medicinal chemistry, the development status and interactions of palladium complexes with DNA are discussed in order to provide guidance and determine structure and antitumor activity relationships for continuing studies of these systems.

Keywords:

Palladium complex, cytotoxicity, N-containing ligands, amino acid ligands, S-donor ligands, P-containing ligands, interactions with DNA, cisplatin.



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Article Details

Volume: 9
Issue Number: 3
First Page: 356
Last Page: 368
Page Count: 13
DOI: 10.2174/1871520610909030356
Price: $58
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