Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

Anti-Cancer Agents in Medicinal Chemistry, 9(3): 246-275.

Author(s): Sanjay K. Srivastava, Vivek Kumar, Shiv K. Agarwal, Rama Mukherjee and Anand C Burman.

Affiliation: Medicinal Chemistry, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad 201010, U.P., India.


In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It was found that C-4, C-6 and C-7 positions in quinazoline are appropriate sites for designing new tyrosine kinase inhibitors. This review should help the medicinal chemist in designing more effective tyrosine kinase inhibitors.

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Article Details

Volume: 9
Issue Number: 3
First Page: 246
Last Page: 275
Page Count: 30
DOI: 10.2174/1871520610909030246
Price: $58

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