Importance and Limitations of Chemotherapy Among the Available Treatments for Gastrointestinal Tumours

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Importance and Limitations of Chemotherapy Among the Available Treatments for Gastrointestinal Tumours

Anti-Cancer Agents in Medicinal Chemistry, 9(2): 162-184.

Author(s): Jose J.G. Marin, Marta R. Romero, Alba G. Blazquez, Elisa Herraez, Emma Keck and Oscar Briz.

Affiliation: Department of Physiology and Pharmacology, Campus Miguel de Unamuno E.I.D. S-09, 37007- Salamanca, Spain.


Gastrointestinal tumours constitute one of the worldwide leading causes of death. One important limitation in the battle against these types of cancer is their lack of sensitivity to currently available chemotherapy and the development of drug resistance during treatment. The mechanisms responsible for this refractivity include a reduction in drug uptake, enhanced drug export, intracellular inactivation of the effective agent, alteration of the molecular target, an increase in the activity of the target route to be inhibited or the appearance or stimulation of alternative routes, enhanced repair of drug-induced modification in the target molecules, and activation/inhibition of intracellular signalling pathways, which leads to a negative balance between apoptosis/survival of tumour cells. A better understanding of these mechanisms is needed in order to develop both accurate tests to predict the lack of response to chemotherapy and novel approaches aimed to overcome the drug resistance of gastrointestinal tumours. The complexity of this issue is further increased owing to the existence of marked differences among the types of primary malignant gastrointestinal tumours and the diversity of tissues from which metastatic cells can access the gut. Moreover, inter-individual variability plus the fact that sensitivity/refractivity may change during the evolution of the tumour further complicate the overall situation. The present article reviews anti-cancer agents used either alone or, more frequently, combined in regimens, as neoadjuvant or postsurgical adjuvant chemotherapy within the context of the available curative and palliative therapeutic options used to treat the most common types of cancer of the gastrointestinal tract and pancreas.


Chemotherapy, Gastrointestinal Tumours, intracellular signalling, metastatic cells, anti-cancer agents, pancreas.

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Article Details

Volume: 9
Issue Number: 2
First Page: 162
Last Page: 184
Page Count: 23
DOI: 10.2174/187152009787313828
Price: $58

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