Cdc25A Protein Phosphatase: A Therapeutic Target for Liver Cancer Therapies

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Cdc25A Protein Phosphatase: A Therapeutic Target for Liver Cancer Therapies

Anti-Cancer Agents in Medicinal Chemistry, 8(8): 863-871.

Author(s): Z. Wang, S. Kar and B I Carr.

Affiliation: Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, Room 519A, Philadelphia, PA, USA.


Cdc25A, a dual specificity protein phosphatase, is well-recognized as a critical regulator for cell cycle progression. We recently found that it also regulates mitogen-activated protein kinase (MAPK) signal transduction pathway. Inhibition of Cdc25A activity by a K vitamin analog Compound 5 (Cpd 5) can induce a strong and prolonged activation of epidermal growth factor receptor (EGFR)- MAPK pathway, which leads to suppression of transcription factors CREB and c-Myc, resulting in decreased expression of Cdc25A and cyclin D1 levels. Our investigations suggest that Cdc25A plays a central role in regulating and linking cell cycle progression and MAPK signal transduction pathways. Several other recently synthesized K vitamin analogs also affect this pathway, including the non-quinone PM20 and fluoro-Cpd 5. Thus, searching for new and efficient small molecules to inhibit Cdc25A activity may provide new means to control cancers of the liver and other sites.


Hepatoma, Cdc25A, compound 5, protein phosphatases, cell growth inhibition, MAP kinase, cell cycle, tyrosine phosphorylation.

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Article Details

Volume: 8
Issue Number: 8
First Page: 863
Last Page: 871
Page Count: 9
DOI: 10.2174/187152008786847675
Price: $58

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