Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?

Anti-Cancer Agents in Medicinal Chemistry, 8(7): 798-806.

Author(s): Andrea Bortolato, Giorgio Cozza and Stefano Moro.

Affiliation: Molecular Modeling Section (MMS), Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, I-35131 Padova, Italy.


Protein kinase CK2 is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. A number of structurally unrelated CK2 inhibitors, tested on a variety of cells derived from tumours, including lymphomas, leukaemias, multiple myeloma and prostate carcinoma, display a proapoptotic effect which is roughly proportional to their in vitro inhibitory potency. In the present review we summarize the most recent discovery of potent and selective CK2 inhibitors and their prospective as future anticancer agents.


Protein kinase CK2, casein kinase 2, anticancer drugs, drug discovery.

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Article Details

Volume: 8
Issue Number: 7
First Page: 798
Last Page: 806
Page Count: 9
DOI: 10.2174/187152008785914761
Price: $58
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