Selenium and Colon Cancer – From Chemoprevention to New Treatment Modality

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Selenium and Colon Cancer – From Chemoprevention to New Treatment Modality

Anti-Cancer Agents in Medicinal Chemistry, 8(6): 598-602.

Author(s): Emil Rudolf, Vera Kralova and Miroslav Cervinka.

Affiliation: Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Simkova 870, 500 38, Hradec Kralove, Czech Republic.


Colorectal cancer is among the most common cancers worldwide, in terms of overall mortality. Environmental factors have been identified to play the most important roles in the development of this disease, in particular diet and its specific components. Selenium is an important micronutrient engaged in the protection of colonic cells against a wide range of external and internal stressors. In addition, selenium has been reported to actively inhibit growth of malignant colonic cells as well as to induce their demise. Furthermore, besides its promising chemopreventive role in the various stages of colorectal cancer development, selected chemical forms of selenium have shown interesting interaction patterns with some cytostatic chemicals or inducers of apoptosis. The advantages of selected selenium preparations thus might reach beyond chemoprevention since they may be used in conjunction with established antioneoplastic drugs, thereby establishing new treatment modality for colorectal cancer. In addition to summarizing our current knowledge about the mechanisms whereby selenium imparts its chemopreventive potential in colon carcinogenesis, the possibilities of a combined use of selenium with other cytostatics and chemicals are discussed.


Colon cancer, selenium, treatment modality, chemoprevention, signaling.

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Article Details

Volume: 8
Issue Number: 6
First Page: 598
Last Page: 602
Page Count: 5
DOI: 10.2174/187152008785133047
Price: $58
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